Purpose: The aim of our study is to compare the efficacy of platelet-rich plasma (PRP) and viscosupplementation (hyaluronic acid [HA]) intra-articular injections for the treatment of knee cartilage degenerative lesions and osteoarthritis (OA). Methods: The study involved 150 patients affected by cartilage degenerative lesions and early and severe OA. Fifty symptomatic patients were treated with 3 autologous PRP intra-articular injections and were evaluated prospectively at enrollment and at 2- and 6-month follow-up. The results obtained were compared with 2 homogeneous groups of patients treated with HA injections. One group was treated with injections of highmolecular weight HA; the other group was treated with lowmolecular weight (LW) HA. International Knee Documentation Committee and EQ VAS scores were used for clinical evaluation; adverse events and patient satisfaction were also recorded. Results: At 2 months' follow-up, the PRP and LW HA groups showed a similar improvement, with higher results compared with the highmolecular weight HA group (P <.005). At 6 months' follow-up, better results were observed in the PRP group (P <.005). PRP and LW HA treatments offered similar results in patients aged over 50 years and in the treatment of advanced OA. PRP showed a better performance compared with HA in younger patients affected by cartilage lesions or early OA. Conclusions: Autologous PRP injections showed more and longer efficacy than HA injections in reducing pain and symptoms and recovering articular function. Better results were achieved in younger and more active patients with a low degree of cartilage degeneration, whereas a worse outcome was obtained in more degenerated joints and in older patients, in whom results similar to those of viscosupplementation have been observed. Level of Evidence: Level II, prospective comparative study. © 2011 Arthroscopy Association of North America.

Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis

Buda R.
Secondo
;
2011

Abstract

Purpose: The aim of our study is to compare the efficacy of platelet-rich plasma (PRP) and viscosupplementation (hyaluronic acid [HA]) intra-articular injections for the treatment of knee cartilage degenerative lesions and osteoarthritis (OA). Methods: The study involved 150 patients affected by cartilage degenerative lesions and early and severe OA. Fifty symptomatic patients were treated with 3 autologous PRP intra-articular injections and were evaluated prospectively at enrollment and at 2- and 6-month follow-up. The results obtained were compared with 2 homogeneous groups of patients treated with HA injections. One group was treated with injections of highmolecular weight HA; the other group was treated with lowmolecular weight (LW) HA. International Knee Documentation Committee and EQ VAS scores were used for clinical evaluation; adverse events and patient satisfaction were also recorded. Results: At 2 months' follow-up, the PRP and LW HA groups showed a similar improvement, with higher results compared with the highmolecular weight HA group (P <.005). At 6 months' follow-up, better results were observed in the PRP group (P <.005). PRP and LW HA treatments offered similar results in patients aged over 50 years and in the treatment of advanced OA. PRP showed a better performance compared with HA in younger patients affected by cartilage lesions or early OA. Conclusions: Autologous PRP injections showed more and longer efficacy than HA injections in reducing pain and symptoms and recovering articular function. Better results were achieved in younger and more active patients with a low degree of cartilage degeneration, whereas a worse outcome was obtained in more degenerated joints and in older patients, in whom results similar to those of viscosupplementation have been observed. Level of Evidence: Level II, prospective comparative study. © 2011 Arthroscopy Association of North America.
File in questo prodotto:
File Dimensione Formato  
Kon, Mandelbaum, Buda 2011 - Platelet-rich Plasma Intra-Articular Injection Vs Hyaluronic Acid.pdf

Solo gestori archivio

Descrizione: Original Article
Tipologia: PDF editoriale
Dimensione 1.9 MB
Formato Adobe PDF
1.9 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/752048
Citazioni
  • ???jsp.display-item.citation.pmc??? 118
  • Scopus 368
  • ???jsp.display-item.citation.isi??? 340
social impact