Nowadays the research of residual solvents present in a pharmaceutical substance is highly recommended by the authorities. The objective was to evaluate the influence of drying conditions on the content of volatile impurities. Several drying processes were carried out on paracetamol recrystallized in three different solvents. The determination of the residual solvent concentration has shown important variations according to the drying processes. The technological properties of the different crystals obtained were also investigated. Compression behaviour does not seem to be influenced by the residual solvent content.
Influence of drying conditions on residual solvent contents in crystals. Part 1: Study on monocrystalline particles
Di Martino P.;
1995-01-01
Abstract
Nowadays the research of residual solvents present in a pharmaceutical substance is highly recommended by the authorities. The objective was to evaluate the influence of drying conditions on the content of volatile impurities. Several drying processes were carried out on paracetamol recrystallized in three different solvents. The determination of the residual solvent concentration has shown important variations according to the drying processes. The technological properties of the different crystals obtained were also investigated. Compression behaviour does not seem to be influenced by the residual solvent content.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
