Brain-derived neurotrophic factor (BDNF) and its precursor proBDNF contribute to brain plasticity and neuronal remodeling. Recently, the ratio between proBDNF and BDNF (RpB) has been proposed as a possible marker in major psychiatric disorders. Convergent lines of evidence suggest neurotrophins alterations could be involved into the pathophysiology of Cocaine Use Disorder (CUD) and insomnia. The aims of the present study are to evaluate the correlations between neurotrophins levels, insomnia and clinical features among CUD patients.
Impact of sleep disorders and disease duration on neurotrophins levels in cocaine use disorder
Miuli, Andrea;Mancusi, Gianluca;Pettorruso, Mauro;Di Carlo, Francesco;D'Andrea, Antea;Pernaci, Giulia;Di Crosta, Teresa;d'Andrea, Giacomo;Bubbico, Giovanna;Martinotti, Giovanni;Giannantonio, Massimo di
2022-01-01
Abstract
Brain-derived neurotrophic factor (BDNF) and its precursor proBDNF contribute to brain plasticity and neuronal remodeling. Recently, the ratio between proBDNF and BDNF (RpB) has been proposed as a possible marker in major psychiatric disorders. Convergent lines of evidence suggest neurotrophins alterations could be involved into the pathophysiology of Cocaine Use Disorder (CUD) and insomnia. The aims of the present study are to evaluate the correlations between neurotrophins levels, insomnia and clinical features among CUD patients.File in questo prodotto:
File | Dimensione | Formato | |
---|---|---|---|
1-s2.0-S0304394022003664-main (1).pdf
accesso aperto
Dimensione
417.08 kB
Formato
Adobe PDF
|
417.08 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.