Background: Sex related differences in the course and severity of multiple sclerosis ( MS) could be mediated by the sex hormones.Objective: To investigate the relation between serum sex hormone concentrations and characteristics of tissue damage on conventional magnetic resonance imaging (MRI) in men and women suffering from relapsing-remitting MS.Results: Serum testosterone was significantly lower in women with MS than in controls. The lowest levels were found in women with a greater number of gadolinium enhancing lesions. A positive correlation was observed between testosterone concentrations and both tissue damage on MRI and clinical disability. In men, there was a positive correlation between oestradiol concentrations and brain damage.Conclusions: The hormone related modulation of pathological changes supports the hypothesis that sex hormones play a role in the inflammation, damage, and repair mechanisms typical of MS.

Sex hormones modulate brain damage in multiple sclerosis: MRI evidence

Tomassini, V;Paolillo, A;
2005-01-01

Abstract

Background: Sex related differences in the course and severity of multiple sclerosis ( MS) could be mediated by the sex hormones.Objective: To investigate the relation between serum sex hormone concentrations and characteristics of tissue damage on conventional magnetic resonance imaging (MRI) in men and women suffering from relapsing-remitting MS.Results: Serum testosterone was significantly lower in women with MS than in controls. The lowest levels were found in women with a greater number of gadolinium enhancing lesions. A positive correlation was observed between testosterone concentrations and both tissue damage on MRI and clinical disability. In men, there was a positive correlation between oestradiol concentrations and brain damage.Conclusions: The hormone related modulation of pathological changes supports the hypothesis that sex hormones play a role in the inflammation, damage, and repair mechanisms typical of MS.
File in questo prodotto:
File Dimensione Formato  
11_JNNP_2005.pdf

accesso aperto

Tipologia: PDF editoriale
Dimensione 119.49 kB
Formato Adobe PDF
119.49 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/803298
Citazioni
  • ???jsp.display-item.citation.pmc??? 35
  • Scopus 125
  • ???jsp.display-item.citation.isi??? 119
social impact