Modulation of inflammatory pathway in human gingival fibroblasts exposed to resinous materials

The goal of this work was to evaluate the anti-inflammatory effects of two resins, Bis-GMA-based resin (ProTemp 4™) and PMMA-based resin (Coldpac), used in dentistry for temporary prosthetics treatments, in the modulation of the inflammatory pathway NFkBp65/NLRP3/IL-1β. The protein expression of inflammatory markers was evaluated in an in vitro model of primary human gingival fibroblasts (hGFs) by immunofluorescence analysis while the study of the ultra-morphological analysis was performed through scanning electron microscopy. Taken together these results may suggest that ProTemp 4™ resin exerts a better performance in terms of inflammatory modulation.