Two glycine residues were appended to two alkyne ligands in a rigid, bimetallic ring that features both a 1,1′-ferrocene and a tungsten bis-alkyne to yield complex 4a-b. The conformation of 4a-b was probed using NMR and computational methods. The results show that the bimetallic ring system holds the two glycine residues in a conformation similar to that found in a parallel β-sheet, and that this conformation is made robust by formation of four intramolecular hydrogen bonds. In contrast, a diester derivative, 13a-b, adopts a conformation where only one of the two NH protons are involved in an intramolecular hydrogen bond. The findings suggest that in 4a-b the bimetallic ring system adopts a nascent β-sheet conformation.
Generation of the intramolecular hydrogen bonding of a parallel β-sheet nucleated by a rigid bimetallic ring
Marrone A.;
2026-01-01
Abstract
Two glycine residues were appended to two alkyne ligands in a rigid, bimetallic ring that features both a 1,1′-ferrocene and a tungsten bis-alkyne to yield complex 4a-b. The conformation of 4a-b was probed using NMR and computational methods. The results show that the bimetallic ring system holds the two glycine residues in a conformation similar to that found in a parallel β-sheet, and that this conformation is made robust by formation of four intramolecular hydrogen bonds. In contrast, a diester derivative, 13a-b, adopts a conformation where only one of the two NH protons are involved in an intramolecular hydrogen bond. The findings suggest that in 4a-b the bimetallic ring system adopts a nascent β-sheet conformation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
