he attached patent application describes an innovative pharmaceutical and nutraceutical delivery platform based on oleuropein (OLP), a natural polyphenolic compound extracted from olive leaves, which are recovered as by-products of the olive oil industry. The invention focuses on the development of lipid-conjugated oleuropein derivatives capable of self-assembling into core–shell nanoparticles for the encapsulation and controlled release of biologically active substances. The patented technology includes: extraction and purification methods for oleuropein from olive leaves; synthesis of amphiphilic oleuropein–lipid conjugates; preparation of nanoparticle-based delivery systems; encapsulation of hydrophilic and lipophilic bioactive compounds; potential applications in pharmaceutical, nutraceutical, cosmetic, food, and medical device fields. The platform was designed to improve the stability, bioavailability, and controlled release of bioactive molecules, overcoming limitations associated with biological membrane permeability and poor solubility. The invention also emphasizes the sustainable valorization of agro-industrial waste derived from the olive oil supply chain, particularly olive leaves and related by-products. Experimental studies reported in the patent include: chemical synthesis and characterization of oleuropein-lipid conjugates; nanoparticle preparation and physicochemical characterization; encapsulation efficiency and release studies; preliminary in vitro biological evaluation on human keratinocyte cell lines. The patent application, entitled “Piattaforma per la veicolazione di sostanze biologicamente attive” (“Platform for the Delivery of Biologically Active Substances”), was filed by AlgoBiotechnologies Srl in 2023.
PIATTAFORMA PER LA VEICOLAZIONE DI SOSTANZE BIOLOGICAMENTE ATTIVE
di stefano antonio
;cacciatore ivana;marinelli lisa;dimmito marilisa pia;di rienzo annalisa;toto eleonora chiara
2023-01-01
Abstract
he attached patent application describes an innovative pharmaceutical and nutraceutical delivery platform based on oleuropein (OLP), a natural polyphenolic compound extracted from olive leaves, which are recovered as by-products of the olive oil industry. The invention focuses on the development of lipid-conjugated oleuropein derivatives capable of self-assembling into core–shell nanoparticles for the encapsulation and controlled release of biologically active substances. The patented technology includes: extraction and purification methods for oleuropein from olive leaves; synthesis of amphiphilic oleuropein–lipid conjugates; preparation of nanoparticle-based delivery systems; encapsulation of hydrophilic and lipophilic bioactive compounds; potential applications in pharmaceutical, nutraceutical, cosmetic, food, and medical device fields. The platform was designed to improve the stability, bioavailability, and controlled release of bioactive molecules, overcoming limitations associated with biological membrane permeability and poor solubility. The invention also emphasizes the sustainable valorization of agro-industrial waste derived from the olive oil supply chain, particularly olive leaves and related by-products. Experimental studies reported in the patent include: chemical synthesis and characterization of oleuropein-lipid conjugates; nanoparticle preparation and physicochemical characterization; encapsulation efficiency and release studies; preliminary in vitro biological evaluation on human keratinocyte cell lines. The patent application, entitled “Piattaforma per la veicolazione di sostanze biologicamente attive” (“Platform for the Delivery of Biologically Active Substances”), was filed by AlgoBiotechnologies Srl in 2023.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
