Cystic fibrosis (CF) is a complex genetic disorder that primarily affects the respiratory and digestive systems, leading to chronic lung inflammation, pathogen infections, and digestive problems. In the lungs, this is also accompanied by chronic pathogen infections. Despite significant advancements, many animal models fail to fully replicate the complexity and progression of CF in humans. This limitation highlights the crucial need for innovative in-vitro approaches to improve CF research. Moreover, with the “FDA Modernization ACT 2.0” the use of complex in vitro cultures has been approved for drug testing in alternative to animal models.
Editorial: Exploring novel in vitro models for cystic fibrosis research
Mattoscio, Domenico
;Plebani, Roberto
2026-01-01
Abstract
Cystic fibrosis (CF) is a complex genetic disorder that primarily affects the respiratory and digestive systems, leading to chronic lung inflammation, pathogen infections, and digestive problems. In the lungs, this is also accompanied by chronic pathogen infections. Despite significant advancements, many animal models fail to fully replicate the complexity and progression of CF in humans. This limitation highlights the crucial need for innovative in-vitro approaches to improve CF research. Moreover, with the “FDA Modernization ACT 2.0” the use of complex in vitro cultures has been approved for drug testing in alternative to animal models.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
