Purpose To explore macular pigment optical density (MPOD) dynamics in stage 2 and stage 3 epiretinal membranes (ERMs) and to evaluate its pre and postoperative modifications. Furthermore, the study assessed the potential of MPOD as a prognostic biomarker in ERM management. Methods A cohort of stage 2 (n=21) and 3 (n=20) ERM patients, matched for age and gender, underwent clinical evaluation at baseline and postoperative followup. Correlations between MPOD and optical coherence tomography parameters were analysed within each group. Results Postoperative MPOD levels significantly differed between stage 2 and 3 ERM patients (p=0.027). Changes in MPOD over time (ΔMPOD) were significantly greater in stage 3 compared with stage 2 participants (p=0.018). In stage 2, ΔMPOD correlated with changes in best-corrected visual acuity (ΔBCVA) (r=0.398, p=0.074) and demonstrated a strong correlation with changes in outer nuclear layer thickness (r=0.672, p<0.001). In stage 3, ΔMPOD exhibited a significant negative correlation with changes in central foveal thickness (r=−0.547, p=0.013) and a positive correlation with ΔBCVA (r=0.510, p=0.022). Conclusions MPOD exhibited stage-specific dynamics and significant postoperative changes. Correlation between ΔMPOD and ΔBCVA in both stages highlights its potential role as a prognostic functional biomarker.
Stage-specific dynamics of macular pigment optical density as a prognostic biomarker in epiretinal membrane surgery
Quarta A.;Toto L.;Gironi M.;Ruggeri M. L.;Porreca A.;Zeppa L.;Ferrante P.;Mastropasqua R.
2025-01-01
Abstract
Purpose To explore macular pigment optical density (MPOD) dynamics in stage 2 and stage 3 epiretinal membranes (ERMs) and to evaluate its pre and postoperative modifications. Furthermore, the study assessed the potential of MPOD as a prognostic biomarker in ERM management. Methods A cohort of stage 2 (n=21) and 3 (n=20) ERM patients, matched for age and gender, underwent clinical evaluation at baseline and postoperative followup. Correlations between MPOD and optical coherence tomography parameters were analysed within each group. Results Postoperative MPOD levels significantly differed between stage 2 and 3 ERM patients (p=0.027). Changes in MPOD over time (ΔMPOD) were significantly greater in stage 3 compared with stage 2 participants (p=0.018). In stage 2, ΔMPOD correlated with changes in best-corrected visual acuity (ΔBCVA) (r=0.398, p=0.074) and demonstrated a strong correlation with changes in outer nuclear layer thickness (r=0.672, p<0.001). In stage 3, ΔMPOD exhibited a significant negative correlation with changes in central foveal thickness (r=−0.547, p=0.013) and a positive correlation with ΔBCVA (r=0.510, p=0.022). Conclusions MPOD exhibited stage-specific dynamics and significant postoperative changes. Correlation between ΔMPOD and ΔBCVA in both stages highlights its potential role as a prognostic functional biomarker.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
