INTRODUCTION: Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD). METHODS: We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers. RESULTS: CD-associated SBA showed a significantly (P < 0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL but only in one SBA. DISCUSSION: Our findings demonstrated a worse prognosis of CD-associated TCL in comparison with CD-associated SBA.
Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease
Santacroce G.;Ciccocioppo R.;Di Sabatino A.;D'Errico A.;Biancone L.;Perfetti V.;Biagi F.;
2025-01-01
Abstract
INTRODUCTION: Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD). METHODS: We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers. RESULTS: CD-associated SBA showed a significantly (P < 0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL but only in one SBA. DISCUSSION: Our findings demonstrated a worse prognosis of CD-associated TCL in comparison with CD-associated SBA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
