Psychosocial predictors oh Health-Related Quality of life in limphoma: a multiple mediation model

Objective: To identify predictors of poorer Health-Related Quality of Life (HRQoL) in lymphoma, focusing on socio-demographic, clinical, and psychosocial variables. Methods: One hundred twenty-six patients with Hodgkin lymphoma or non-Hodgkin lymphoma completed the EORTC QLQ-C30, Hospital Anxiety and Depression Scale, and Multidimensional Scale of Perceived Social Support. Results: Depressive symptoms were significantly associated with poorer HRQoL (β = -0.54, p<0.001). Perceived social support was associated with lower depression and anxiety (β = -0.34, p<0.001; β = -0.19, p<0.01, respectively). Mediation analysis indicated that social support was indirectly associated with HRQoL, through depressive symptoms (β = 0.30, p<0.001). Conclusion: Depressive symptoms showed a significant association with poorer HRQoL in lymphoma. Perceived Social support was associated with better HRQoL through its association with lower depressive symptoms. Identifying individuals at risk can inform targeted, timely psychosocial interventions to reduce distress and improve overall well-being. Findings support routine screening and monitoring in hematology care.