CARRADORI, SIMONE
 Distribuzione geografica
Continente #
EU - Europa 2.142
AS - Asia 591
NA - Nord America 469
AF - Africa 113
SA - Sud America 25
OC - Oceania 10
Totale 3.350
Nazione #
IT - Italia 930
US - Stati Uniti d'America 432
NL - Olanda 264
FR - Francia 254
RU - Federazione Russa 250
IN - India 203
SE - Svezia 136
IE - Irlanda 101
VN - Vietnam 93
TH - Thailandia 49
DE - Germania 33
GB - Regno Unito 29
IQ - Iraq 26
NG - Nigeria 26
PK - Pakistan 24
UA - Ucraina 24
EG - Egitto 23
KR - Corea 21
SA - Arabia Saudita 21
PL - Polonia 20
TR - Turchia 20
DZ - Algeria 18
ID - Indonesia 18
CZ - Repubblica Ceca 17
CN - Cina 15
RO - Romania 15
ZA - Sudafrica 14
HK - Hong Kong 13
HN - Honduras 13
CA - Canada 12
IR - Iran 12
FI - Finlandia 11
JP - Giappone 11
AU - Australia 10
LT - Lituania 9
MA - Marocco 9
MK - Macedonia 9
AR - Argentina 8
MX - Messico 8
PH - Filippine 8
SG - Singapore 8
AE - Emirati Arabi Uniti 7
BE - Belgio 7
CI - Costa d'Avorio 7
TW - Taiwan 7
HR - Croazia 6
BR - Brasile 5
BD - Bangladesh 4
EC - Ecuador 4
HU - Ungheria 4
JM - Giamaica 4
JO - Giordania 4
MY - Malesia 4
RS - Serbia 4
UZ - Uzbekistan 4
YE - Yemen 4
AF - Afghanistan, Repubblica islamica di 3
CL - Cile 3
GH - Ghana 3
GR - Grecia 3
LK - Sri Lanka 3
PE - Perù 3
SD - Sudan 3
AT - Austria 2
BG - Bulgaria 2
CH - Svizzera 2
ES - Italia 2
KW - Kuwait 2
NA - Namibia 2
NP - Nepal 2
SI - Slovenia 2
SK - Slovacchia (Repubblica Slovacca) 2
TN - Tunisia 2
AM - Armenia 1
BA - Bosnia-Erzegovina 1
BJ - Benin 1
BW - Botswana 1
CM - Camerun 1
CO - Colombia 1
DK - Danimarca 1
ET - Etiopia 1
GE - Georgia 1
IL - Israele 1
KH - Cambogia 1
NO - Norvegia 1
PS - Palestinian Territory 1
PT - Portogallo 1
SC - Seychelles 1
VE - Venezuela 1
ZW - Zimbabwe 1
Totale 3.350
Città #
Chieti 476
Saint Petersburg 216
Stockholm 126
Dublin 100
Ashburn 97
Dong Ket 78
Boardman 64
Milan 29
Pescara 29
Rome 26
Council Bluffs 25
Chennai 20
Florence 19
New Delhi 19
Amsterdam 16
Bari 16
San Jose 15
Paris 14
Teramo 14
Jakarta 13
Mumbai 13
Baghdad 12
Turin 12
Bangkok 11
Lucknow 11
Bengaluru 10
Helsinki 10
Katsina 10
Lagos 10
Ban Lup 9
Bologna 9
Frankfurt am Main 9
Hyderabad 9
Lanciano 9
Los Angeles 9
Medina 9
San Vito Chietino 9
Hong Kong 8
Karachi 8
Naples 8
Pune 8
Redmond 8
Abidjan 7
Avellaneda 7
Ban Du 7
Camden 7
Campobasso 7
Columbus 7
Delhi 7
New York 7
Riyadh 7
St Petersburg 7
Busan 6
Città Sant'Angelo 6
Istanbul 6
Moscow 6
Seattle 6
Skopje 6
Vilnius 6
Caserta 5
Henderson 5
Jeddah 5
Kingston 5
Kolkata 5
Kottayam 5
Nan 5
Nowon-gu 5
Perugia 5
Reggio Emilia 5
San Pedro Sula 5
Sharjah 5
Sydney 5
Tehran 5
Amman 4
Cape Town 4
Chicago 4
Constantine 4
Da Nang 4
Dhaka 4
Erzurum 4
Ferrara 4
Guadalajara 4
Hanoi 4
Houston 4
Johannesburg 4
London 4
Multan 4
Penne 4
San Martino Valle Caudina 4
Seoul 4
Singapore 4
Sunnyvale 4
Taipei 4
Tegucigalpa 4
Thrissur 4
Villa Elce 4
Visakhapatnam 4
Warsaw 4
Wilmington 4
Accra 3
Totale 1.912
Nome #
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase, file e4233f18-597b-2860-e053-6605fe0a460a 490
Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment, file e4233f18-08b1-2860-e053-6605fe0a460a 152
Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis, file e4233f17-2460-2860-e053-6605fe0a460a 134
Tagetes spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity, file e4233f17-022c-2860-e053-6605fe0a460a 120
New Frontiers in Selective Human MAO-B Inhibitors, file e4233f19-2a38-2860-e053-6605fe0a460a 116
Effects of the Hydroethanolic Extract of Lycopodium selago L. on Scopolamine-Induced Memory Deficits in Zebrafish, file e4233f18-daef-2860-e053-6605fe0a460a 99
Development of novel techniques to extract phenolic compounds from Romanian cultivars of Prunus domestica L. and their biological properties, file e4233f18-e930-2860-e053-6605fe0a460a 85
Liquid phase and microwave-assisted extractions for multi-component phenolic pattern determination of five Romanian Galium species coupled with bioassays, file e4233f17-108d-2860-e053-6605fe0a460a 78
Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review, file 0386fb9d-8d27-4929-843e-dbad6b45167d 59
Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents, file e4233f17-b5de-2860-e053-6605fe0a460a 55
Development of thiazolidinones as fungal carbonic anhydrase inhibitors, file e4233f17-838b-2860-e053-6605fe0a460a 52
Selective Inhibition of Helicobacter pylori Carbonic Anhydrases by Carvacrol and Thymol Could Impair Biofilm Production and the Release of Outer Membrane Vesicles, file e4233f18-841b-2860-e053-6605fe0a460a 48
Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection, file e4233f18-9dfd-2860-e053-6605fe0a460a 47
Design, synthesis and biological evaluation of aromatase inhibitors based on sulfonates and sulfonamides of resveratrol, file e4233f18-7e82-2860-e053-6605fe0a460a 43
C-Myc Expression in Oral Squamous Cell Carcinoma: Molecular Mechanisms in Cell Survival and Cancer Progression, file e9571a0a-d7da-4ce8-b6d2-3ade9474c805 43
Analysis of imidazoles and triazoles in biological samples after MicroExtraction by Packed Sorbent, file e4233f16-8448-2860-e053-6605fe0a460a 42
null, file e4233f18-a76a-2860-e053-6605fe0a460a 38
Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity, file e4233f17-e9dc-2860-e053-6605fe0a460a 37
Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies, file d736a0ef-6ac8-457e-b99d-f94d70aade00 36
Identification and characterization of the α-CA in the outer membrane vesicles produced by Helicobacter pylori, file e4233f17-0e90-2860-e053-6605fe0a460a 35
Chemical characterization, antioxidant properties, anti-inflammatory activity, and enzyme inhibition of Ipomoea batatas L. leaf extracts, file e4233f16-8a9b-2860-e053-6605fe0a460a 34
Water extract from inflorescences of industrial hemp futura 75 variety as a source of anti-inflammatory, anti-proliferative and antimycotic agents: Results from in silico, in vitro and ex vivo studies, file e4233f17-a44e-2860-e053-6605fe0a460a 29
Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives, file e4233f19-2a3a-2860-e053-6605fe0a460a 28
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents, file e4233f19-471b-2860-e053-6605fe0a460a 28
Kinesin Eg5 Selective Inhibition by Newly Synthesized Molecules as an Alternative Approach to Counteract Breast Cancer Progression: An In Vitro Study, file 7a46e2c9-900d-4f52-b808-dc1f7c3b7b89 27
Chemical constituents and biological activities of sage species: A comparison between Salvia officinalis L., S. glutinosa L. and S.transsylvanica (Schur ex Griseb. & Schenk) Schur, file e4233f17-9c09-2860-e053-6605fe0a460a 27
Dual carbonic anhydrase ix/xii inhibitors and carbon monoxide releasing molecules modulate LPS-mediated inflammation in mouse macrophages, file e4233f18-3e11-2860-e053-6605fe0a460a 27
Evaluation of processing effects on anthocyanin content and colour modifications of blueberry (Vaccinium spp.) extracts: Comparison between HPLC-DAD and CIELAB analyses, file e4233f19-277a-2860-e053-6605fe0a460a 27
Multiple pharmacognostic characterization on hemp commercial cultivars: Focus on inflorescence water extract activity, file e4233f17-0f72-2860-e053-6605fe0a460a 26
Antimicrobial and Antibiofilm Activities of New Synthesized Silver Ultra-NanoClusters (SUNCs) Against Helicobacter pylori, file e4233f17-d51a-2860-e053-6605fe0a460a 26
Dual Acting Carbon Monoxide Releasing Molecules and Carbonic Anhydrase Inhibitors Differentially Modulate Inflammation in Human Tenocytes, file e4233f18-4733-2860-e053-6605fe0a460a 26
Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?, file 563604aa-e6ca-4590-ab76-c2a640d8c23d 25
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis, file e4233f17-0f18-2860-e053-6605fe0a460a 25
Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy, file e4233f18-90a1-2860-e053-6605fe0a460a 25
Phytocomplex Characterization and Biological Evaluation of Powdered Fruits and Leaves from Elaeagnus angustifolia, file e4233f17-8ee3-2860-e053-6605fe0a460a 24
Use of innovative (micro)extraction techniques to characterize Harpagophytum procumbens root and its commercial food supplements, file e4233f19-7740-2860-e053-6605fe0a460a 24
Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents, file e4233f15-ae71-2860-e053-6605fe0a460a 23
Chromatographic analyses, in vitro biological activities and cytotoxicity of Cannabis sativa L. essential oil: a multidisciplinary study, file e4233f17-049f-2860-e053-6605fe0a460a 23
The Up-Regulation of Oxidative Stress as a Potential Mechanism of Novel MAO-B Inhibitors for Glioblastoma Treatment, file e4233f17-1e09-2860-e053-6605fe0a460a 22
The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer, file e4233f17-5d24-2860-e053-6605fe0a460a 22
Characterization of arils juice and peel decoction of fifteen varieties of punica Granatum L.: A focus on anthocyanins, ellagitannins and polysaccharides, file e4233f17-82a6-2860-e053-6605fe0a460a 22
Synthesis, cytotoxicity and anti−proliferative activity against ags cells of new 3(2h)−pyridazinone derivatives endowed with a piperazinyl linker, file e4233f18-75e2-2860-e053-6605fe0a460a 22
Novel Biologically Active Molecules, Biomaterials, and Nanoparticles for Microbial Biofilm Control in Human Medicine, file e4233f18-bcb6-2860-e053-6605fe0a460a 22
Cannabis sativa L. inflorescences from monoecious cultivars grown in Central Italy: an untargeted chemical characterization from early flowering to ripening, file e4233f17-7a85-2860-e053-6605fe0a460a 21
Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies, file e4233f18-7444-2860-e053-6605fe0a460a 21
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles, file e4233f17-0f1a-2860-e053-6605fe0a460a 20
Characterization and Valorization of ‘Sulmona Red Garlic’ Peels and Small Bulbs, file 983621ce-a0af-4219-9cca-e633752e3797 19
Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model, file e4233f19-1b5a-2860-e053-6605fe0a460a 19
Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships, file d1e1cf4e-7528-4fc9-9003-5c2ae83364a7 18
Elucidation of the mechanisms governing the thermal diastereomerization of bioactive chiral 1,3,4-thiadiazoline spiro-cyclohexyl derivatives towards their anancomeric stereoisomers, file e4233f15-adf1-2860-e053-6605fe0a460a 18
A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts, file e4233f16-9ac2-2860-e053-6605fe0a460a 18
Are there any therapeutic options currently available for Wuhan coronavirus?, file e4233f18-037f-2860-e053-6605fe0a460a 18
Pomegranate Fruit Cracking during Maturation: From Waste to Valuable Fruits, file 9b17b61b-fc21-45a6-80ab-0f40db5ed7ee 17
Polyphenols from Lycium barbarum (Goji) Fruit European Cultivars at Different Maturation Steps: Extraction, HPLC-DAD Analyses, and Biological Evaluation, file e4233f17-509b-2860-e053-6605fe0a460a 17
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation, file e4233f17-e70e-2860-e053-6605fe0a460a 17
Metabolomic profile and antioxidant/anti-inflammatory effects of industrial hemp water extract in fibroblasts, keratinocytes and isolated mouse skin specimens, file e4233f18-3836-2860-e053-6605fe0a460a 17
Biological investigation of N-methyl thiosemicarbazones as antimicrobial agents and bacterial carbonic anhydrases inhibitors, file e4233f19-3a09-2860-e053-6605fe0a460a 17
In Vitro Activity of the Arylaminoartemisinin GC012 against Helicobacter pylori and Its Effects on Biofilm, file e4233f19-7566-2860-e053-6605fe0a460a 17
Correlation between the antimicrobial activity and metabolic profiles of cell free supernatants and membrane vesicles produced by lactobacillus reuteri DSM 17938, file e4233f18-0a2e-2860-e053-6605fe0a460a 16
Synthesis and biological evaluation of carvacrol-based derivatives as dual inhibitors of H. Pylori strains and ags cell proliferation, file e4233f18-20a7-2860-e053-6605fe0a460a 16
Synthesis and Evaluation of Thymol-Based Synthetic Derivatives as Dual-Action Inhibitors against Different Strains of H. pylori and AGS Cell Line, file e4233f18-804d-2860-e053-6605fe0a460a 16
Drug repurposing, an attractive strategy in pancreatic cancer treatment: Preclinical and clinical updates, file e4233f18-97d7-2860-e053-6605fe0a460a 16
Antimicrobial and Antibiofilm Activities of Carvacrol, Amoxicillin and Salicylhydroxamic Acid Alone and in Combination vs. Helicobacter pylori: Towards a New Multi-Targeted Therapy, file b599f5c0-4225-4261-b3a2-3213af9d84bd 15
Optimization of Aqueous Extraction and Biological Activity of Harpagophytum procumbens Root on Ex Vivo Rat Colon Inflammatory Model, file e4233f16-3916-2860-e053-6605fe0a460a 15
Identification of new anti-Candida compounds by ligand-based pharmacophore virtual screening, file e4233f15-b510-2860-e053-6605fe0a460a 14
Curcumin: Total-Scale Analysis of the Scientific Literature, file e4233f17-176f-2860-e053-6605fe0a460a 14
Kinesin Eg5 targeting inhibitors as a new strategy for gastric adenocarcinoma treatment, file e4233f17-5b7b-2860-e053-6605fe0a460a 14
Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells, file e4233f17-9d04-2860-e053-6605fe0a460a 14
Phenylsulfonimide PPARα Antagonists Enhance Nrf2 Activation and Promote Oxidative Stress-Induced Apoptosis/Pyroptosis in MCF7 Breast Cancer Cells, file 62990d7b-7ac7-4e57-bfc3-b658f14ada32 13
Graminex pollen: phenolic pattern, colorimetric analysis and protective effects in immortalized prostate cells (PC3) and rat prostate challenged with LPS, file e4233f16-ce36-2860-e053-6605fe0a460a 13
Chemical and bioinformatics analyses of the anti-leishmanial and anti-oxidant activities of hemp essential oil, file e4233f18-4120-2860-e053-6605fe0a460a 13
Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori, file e4233f18-7dbe-2860-e053-6605fe0a460a 13
Relevance of Cellular Redox Homeostasis for Vital Functions of Human Dental Pulp Cells, file e4233f18-e2e2-2860-e053-6605fe0a460a 13
Multiple pharmacognostic characterization on hemp commercial cultivars: Focus on inflorescence water extract activity, file e4233f18-ef77-2860-e053-6605fe0a460a 13
Optimization of Aqueous Extraction and Biological Activity of Harpagophytum procumbens Root on Ex Vivo Rat Colon Inflammatory Model, file e4233f19-3596-2860-e053-6605fe0a460a 13
Crocus sativus, Serenoa repens and Pinus massoniana extracts modulate inflammatory response in isolated rat prostate challenged with LPS, file e4233f16-4e67-2860-e053-6605fe0a460a 12
Optimization of ultrasonic extraction to obtain erinacine a and polyphenols with antioxidant activity from the fungal biomass of hericium erinaceus, file e4233f18-51d5-2860-e053-6605fe0a460a 12
New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study, file e4233f18-7ec0-2860-e053-6605fe0a460a 12
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells, file e4233f15-b216-2860-e053-6605fe0a460a 11
Commercial hemp seed oils: A multimethodological characterization, file e4233f18-0292-2860-e053-6605fe0a460a 11
Amine-and amino acid-based compounds as carbonic anhydrase activators, file e4233f18-894c-2860-e053-6605fe0a460a 11
Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential, file e4233f18-fb92-2860-e053-6605fe0a460a 11
Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies, file e4233f19-0346-2860-e053-6605fe0a460a 11
Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties, file e4233f19-4716-2860-e053-6605fe0a460a 11
Crocus sativus L. stigmas and byproducts: Qualitative fingerprint, antioxidant potentials and enzyme inhibitory activities, file e4233f16-cd3c-2860-e053-6605fe0a460a 10
Azole-Based Compounds That Are Active against Candida Biofilm: In Vitro, In Vivo and In Silico Studies, file 316c5ae3-b0ae-4272-be99-c90e84200fce 9
Natural and Synthetic Xanthone Derivatives Counteract Oxidative Stress via Nrf2 Modulation in Inflamed Human Macrophages, file 8b642a7a-742b-4f66-9ad3-8c0705b6e4ff 8
Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential, file e4233f15-fca1-2860-e053-6605fe0a460a 8
Saffron Samples of Different Origin: An NMR Study of Microwave-Assisted Extracts, file e4233f16-728e-2860-e053-6605fe0a460a 8
Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis, file e4233f16-ed0d-2860-e053-6605fe0a460a 8
Antibiofilm activity and NMR-based metabolomic characterization of cell-free supernatant of Limosilactobacillus reuteri DSM 17938, file 26b1efab-fb5a-477a-9ba8-bcc00e7dca62 7
Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies, file 4d38bf4e-bfe9-4c53-9cb7-9715beefcfb0 7
Design, Synthesis and Biological Assessment of Rhodanine-Linked Benzenesulfonamide Derivatives as Selective and Potent Human Carbonic Anhydrase Inhibitors, file 77ca580a-c8d7-498a-a535-f9196ee6120d 7
Development of novel techniques to extract phenolic compounds from Romanian cultivars of Prunus domestica L. and their biological properties, file e4233f16-ddb2-2860-e053-6605fe0a460a 7
A novel class of dual-acting DCH-CORMs counteracts oxidative stress-induced inflammation in human primary tenocytes, file e4233f18-9bc7-2860-e053-6605fe0a460a 7
Nature as a source and inspiration for human monoamine oxidase B (hMAO-B) inhibition: A review of the recent advances in chemical modification of natural compounds, file a16a941a-c106-4068-88cc-bba5a87ddbd4 6
Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents, file e4233f18-925c-2860-e053-6605fe0a460a 6
Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment, file e4233f18-b3b9-2860-e053-6605fe0a460a 6
Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation, file e4233f18-d4d6-2860-e053-6605fe0a460a 6
Crocus sativus L. stigmas and byproducts: Qualitative fingerprint, antioxidant potentials and enzyme inhibitory activities, file e4233f19-25be-2860-e053-6605fe0a460a 6
Totale 3.126
Categoria #
all - tutte 10.263
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 10.263


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20199 0 0 0 0 0 0 0 0 0 1 5 3
2019/202058 1 2 5 1 0 0 0 0 12 16 8 13
2020/2021627 5 5 9 8 13 6 6 6 17 15 107 430
2021/2022443 24 33 45 31 48 31 18 25 47 19 27 95
2022/2023842 50 11 16 43 42 126 150 56 50 49 198 51
2023/20241.274 70 75 60 116 148 227 178 100 161 139 0 0
Totale 3.396