A one-pot methodology for the synthesis of polyfunctionalized indole derivatives by a TiCl4/Et3N-promoted trimolecular condensation of aldehydes, indole heterocycles, and various activated carbonyl compounds is reported. Rationalization of these reactions and extension to other heterocyclic systems is also described.
TiCl4/Et3N-Promoted Three-Component Condensation between Aromatic Heterocycles, Aldehydes, and Active Methylene Compounds
RENZETTI, Andrea;FONTANA, Antonella;DE MARIA, Paolo;
2008-01-01
Abstract
A one-pot methodology for the synthesis of polyfunctionalized indole derivatives by a TiCl4/Et3N-promoted trimolecular condensation of aldehydes, indole heterocycles, and various activated carbonyl compounds is reported. Rationalization of these reactions and extension to other heterocyclic systems is also described.File in questo prodotto:
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