A simple strategy for preparing potential drug delivery systems is presented which appears to be a good alternative to stealth liposomes in terms of stability in buffered aqueous solutions. Microcapsules have been prepared by deposition of shortened and polyethylene glycol-derivatized nanotubes onto positively charged multilamellar vesicles using the layer-by-layer technique. The stability of microcapsules has been determined turbidimetrically by measuring the rate of microcapsule breakdown induced by addition of a destabilizing agent such as the nonionic surfactant octaethyleneglycol mono-n-dodecyl ether. The investigated microcapsules have proven to be more stable than both pure liposomes and stealth liposomes.
Layer-by-layer deposition of shortened nanotubes or polyethylene glycol-derivatized nanotubes on liposomes: A tool for increasing liposome stability
ANGELINI, Guido;BONCOMPAGNI, SIMONA;DE MARIA, Paolo;FONTANA, Antonella;GASBARRI, Carla;
2007-01-01
Abstract
A simple strategy for preparing potential drug delivery systems is presented which appears to be a good alternative to stealth liposomes in terms of stability in buffered aqueous solutions. Microcapsules have been prepared by deposition of shortened and polyethylene glycol-derivatized nanotubes onto positively charged multilamellar vesicles using the layer-by-layer technique. The stability of microcapsules has been determined turbidimetrically by measuring the rate of microcapsule breakdown induced by addition of a destabilizing agent such as the nonionic surfactant octaethyleneglycol mono-n-dodecyl ether. The investigated microcapsules have proven to be more stable than both pure liposomes and stealth liposomes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
