The rates of iodination of 2-acetylimidazole (2AI) are independent of iodine concentration and the reaction is general base-catalysed. This shows that the rate-determining step is the enolisation or ionisation of the C-H bond adjacent to the carbonyl group. In dilute hydrochloric acid and in acetate buffers the enolisation of 2AI occurs with N-protonation rather than O-protonation.
Titolo: | Acid-base and metal ion catalysis in the enolisation of 2-acetylimidazole | |
Autori: | ||
Data di pubblicazione: | 1996 | |
Rivista: | ||
Abstract: | The rates of iodination of 2-acetylimidazole (2AI) are independent of iodine concentration and the reaction is general base-catalysed. This shows that the rate-determining step is the enolisation or ionisation of the C-H bond adjacent to the carbonyl group. In dilute hydrochloric acid and in acetate buffers the enolisation of 2AI occurs with N-protonation rather than O-protonation. | |
Handle: | http://hdl.handle.net/11564/120286 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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