We demonstrated that ConA-induced suppressor cell function is decreased in dysiimune polyneuropathies (D-PNP) during relapses or progression. Plasma exchange (PE) and prednisone are effective in D-PNP. In this study we investigated suppressor cell function in 11 idiopathic CIDP (8 men and 3 women; age 48.4±21.5, range 11-75 yrs) and in 5 paraproteinemic neuropathies with antisulfated glucuronyl paragloboside antibodies (anti-SGPG) (all men; age 63.4±9.2, range 4973) before and after treatment(at 2 weeks for PE, 3 pts; at 3-6 months for prednisone, 13 pts). After treatment suppressor cell function significantly increased in both groups (CIDP=21±4.1 vs 40.18±5.01, p=0.0001; anti-SGPG=15.6±4.2 vs 39.6±5.07, p= 0.0002). In 1 CIDP patient a relapse during treatment tapering, was associated with decreased suppressor activity. In dysimmune neuropathies suppressor cell function correlates inversely with disease activity and shows a favourable response to treatment.
Plasma exchange and prednisone improve suppressor cell function in dysimmune neuropathies
DE LUCA, Giovanna;LUGARESI, Alessandra;UNCINI, Antonino;GAMBI, Domenico
1997-01-01
Abstract
We demonstrated that ConA-induced suppressor cell function is decreased in dysiimune polyneuropathies (D-PNP) during relapses or progression. Plasma exchange (PE) and prednisone are effective in D-PNP. In this study we investigated suppressor cell function in 11 idiopathic CIDP (8 men and 3 women; age 48.4±21.5, range 11-75 yrs) and in 5 paraproteinemic neuropathies with antisulfated glucuronyl paragloboside antibodies (anti-SGPG) (all men; age 63.4±9.2, range 4973) before and after treatment(at 2 weeks for PE, 3 pts; at 3-6 months for prednisone, 13 pts). After treatment suppressor cell function significantly increased in both groups (CIDP=21±4.1 vs 40.18±5.01, p=0.0001; anti-SGPG=15.6±4.2 vs 39.6±5.07, p= 0.0002). In 1 CIDP patient a relapse during treatment tapering, was associated with decreased suppressor activity. In dysimmune neuropathies suppressor cell function correlates inversely with disease activity and shows a favourable response to treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
