Crocus sativus L. is known in herbal medicine for the various pharmacological effects of its components, but no data are found in literature about its biological properties toward Helicobacter pylori, Plasmodium spp. and Leishmania spp. In this work, the potential antibacterial and anti-parasitic effects of crocin and safranal, two important bioactive components in C. sativus, were explored, and also some semi-synthetic derivatives of safranal were tested in order to establish which modifications in the chemical structure could improve the biological activity. According to our promising results, we virtually screened our compounds by means of molecular modeling studies against the main H. pylori enzymes in order to unravel their putative mechanism of action.

Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents

Carradori, Simone;Mollica, Adriano;Luisi, Grazia;
2015-01-01

Abstract

Crocus sativus L. is known in herbal medicine for the various pharmacological effects of its components, but no data are found in literature about its biological properties toward Helicobacter pylori, Plasmodium spp. and Leishmania spp. In this work, the potential antibacterial and anti-parasitic effects of crocin and safranal, two important bioactive components in C. sativus, were explored, and also some semi-synthetic derivatives of safranal were tested in order to establish which modifications in the chemical structure could improve the biological activity. According to our promising results, we virtually screened our compounds by means of molecular modeling studies against the main H. pylori enzymes in order to unravel their putative mechanism of action.
File in questo prodotto:
File Dimensione Formato  
bioactive compounds from Saffron 2015.pdf

accesso aperto

Tipologia: PDF editoriale
Dimensione 931.25 kB
Formato Adobe PDF
931.25 kB Adobe PDF Visualizza/Apri
Scopus - Document details.pdf

Solo gestori archivio

Descrizione: attestazione di Bronze Open Access
Tipologia: Documento in Post-print
Dimensione 354.6 kB
Formato Adobe PDF
354.6 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/641930
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 47
social impact