Mitochondrial DNA (mtDNA) plays a key role in the development of a competent oocyte. In this study, the complete mtDNA sequence obtained for the first time by multiple displacement amplification approach in combination with next-generation sequencing from a single human oocyte is reported (GenBank accession no. KT364276). The analysis of oocyte mitochondria' mutations could provide a better understanding of the genetic variants correlated with the oocyte quality.

Complete sequence of human mitochondrial DNA obtained by combining multiple displacement amplification and next-generation sequencing on a single oocyte

D'AURORA, MARCO;STUPPIA, Liborio;GATTA, Valentina
Ultimo
2017-01-01

Abstract

Mitochondrial DNA (mtDNA) plays a key role in the development of a competent oocyte. In this study, the complete mtDNA sequence obtained for the first time by multiple displacement amplification approach in combination with next-generation sequencing from a single human oocyte is reported (GenBank accession no. KT364276). The analysis of oocyte mitochondria' mutations could provide a better understanding of the genetic variants correlated with the oocyte quality.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/667354
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