Background and Aims: Elastography is a common tecnique used to measure the hepatic stiffness. Little space in research and in the clinic was given to the evalutaion of CV risk and lipid profile in patients with hepatic diseases. The study has the aim to analyze the relationship between elastographic data in patients with liver disease and lipid profile. Methods: 123 patients were recruited in the Internistic Ultrasound of Chieti. They were affected by different liver diseases, in particular hepatitis C and NALFD. A B-mode ultrasound and an elastography exam were per- fomed. Blood samples to investigate lipid profile were collected. Patients with NALFD underwent to a therapeutic strategy with diet and physical activity repeating the ultrasound and the elastographic examination 4 months after the beginnig of therapeutic intervention. Results: The liver elastographic data obtained by patients with hepatic diseases were inversely correlated to levels of total cholesterol with an important statistically significance. Moreover, in patients with Hepatitis C elastographic data were inversely correlated to platelets levels. Another important result was shown by patients with NALFD underwent to a therapeutic strategy with diet and physical activity; at the ultrasound and elastographic controls 4 months after the beginning of diet and physical activity, the liver stiffness decreased with a directly proportional decrease of levels of cholesterol (total and LDL) and increase of HDL. Conclusions: Our study have shown interesting relationships between liver stiffness and lipid profile in patients with different liver diseases. Further studies are needed to better investigate our results.

The fascinating relationship between liver stiffness and cholesterol

213. D’Ardes D;Cocco G;Berdini G;Rossi I;Cipollone F;Schiavone C;Bucci M.
2020-01-01

Abstract

Background and Aims: Elastography is a common tecnique used to measure the hepatic stiffness. Little space in research and in the clinic was given to the evalutaion of CV risk and lipid profile in patients with hepatic diseases. The study has the aim to analyze the relationship between elastographic data in patients with liver disease and lipid profile. Methods: 123 patients were recruited in the Internistic Ultrasound of Chieti. They were affected by different liver diseases, in particular hepatitis C and NALFD. A B-mode ultrasound and an elastography exam were per- fomed. Blood samples to investigate lipid profile were collected. Patients with NALFD underwent to a therapeutic strategy with diet and physical activity repeating the ultrasound and the elastographic examination 4 months after the beginnig of therapeutic intervention. Results: The liver elastographic data obtained by patients with hepatic diseases were inversely correlated to levels of total cholesterol with an important statistically significance. Moreover, in patients with Hepatitis C elastographic data were inversely correlated to platelets levels. Another important result was shown by patients with NALFD underwent to a therapeutic strategy with diet and physical activity; at the ultrasound and elastographic controls 4 months after the beginning of diet and physical activity, the liver stiffness decreased with a directly proportional decrease of levels of cholesterol (total and LDL) and increase of HDL. Conclusions: Our study have shown interesting relationships between liver stiffness and lipid profile in patients with different liver diseases. Further studies are needed to better investigate our results.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/747194
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