The temporal lobe plays a central role in the regulation of the "Central Autonomic Network" and cardiovascular functions. The blockade of glutamatergic pathways in the temporal lobe affects cardio-autonomic control. Perampanel (PER) is a non-competitive agonist of the AMPA receptor. This study evaluated PER effects on cardiac autonomic control in patients affected by drug-resistant TLE (DRTLE).

Perampanel enhances the cardiovagal tone and heart rate variability (HRV) in patients with drug-resistant temporal lobe epilepsy

Dono, Fedele
;
Evangelista, Giacomo;Consoli, Stefano;Rodorigo, Davide;Russo, Mirella;Carrarini, Claudia;Di Pietro, Martina;Anzellotti, Francesca;Onofrj, Marco;Di Iorio, Angelo;Sensi, Stefano L;Frazzini, Valerio;
2022-01-01

Abstract

The temporal lobe plays a central role in the regulation of the "Central Autonomic Network" and cardiovascular functions. The blockade of glutamatergic pathways in the temporal lobe affects cardio-autonomic control. Perampanel (PER) is a non-competitive agonist of the AMPA receptor. This study evaluated PER effects on cardiac autonomic control in patients affected by drug-resistant TLE (DRTLE).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/786672
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