Extracellular Vesicles (EVs) are circulating particles surrounded by a plasma membrane carrying a cargo consisting of proteins, lipids, RNAs, and DNA fragments, stemming from the cells from which they originated. EV factors (i.e., miRNAs) play relevant roles in intercellular crosstalk, both locally and systemically. As EVs increasingly gained attention as potential carriers for targeted genes, the study of EV effects on the host immune response became more relevant. It has been demonstrated that EVs regulate the host immune response, executing both pro- and anti-inflammatory functions. It is also known that physical exercise triggers anti-inflammatory effects. This review underlines the role of circulating EVs as players in the anti-inflammatory events associated with the regulation of the host’s immune response to physical exercise.

Extracellular Vesicles as Players in the Anti-Inflammatory Inter-Cellular Crosstalk Induced by Exercise Training

Catitti, Giulia;De Bellis, Domenico;Vespa, Simone;Simeone, Pasquale
;
Lanuti, Paola
2022-01-01

Abstract

Extracellular Vesicles (EVs) are circulating particles surrounded by a plasma membrane carrying a cargo consisting of proteins, lipids, RNAs, and DNA fragments, stemming from the cells from which they originated. EV factors (i.e., miRNAs) play relevant roles in intercellular crosstalk, both locally and systemically. As EVs increasingly gained attention as potential carriers for targeted genes, the study of EV effects on the host immune response became more relevant. It has been demonstrated that EVs regulate the host immune response, executing both pro- and anti-inflammatory functions. It is also known that physical exercise triggers anti-inflammatory effects. This review underlines the role of circulating EVs as players in the anti-inflammatory events associated with the regulation of the host’s immune response to physical exercise.
2022
Inglese
ELETTRONICO
23
14098
12
extracellular vesicles; inflammation; physical exercise
https://www.mdpi.com/1422-0067/23/22/14098
no
6
263
Catitti, Giulia; De Bellis, Domenico; Vespa, Simone; Simeone, Pasquale; Canonico, Barbara; Lanuti, Paola
info:eu-repo/semantics/article
1 Contributo su Rivista::1.2 Recensione in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11564/793852
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