Background: Cognitive inhibition is key to cognitive control in healthy and psychiatric conditions. Bipolar Disorder (BD) individuals display a range of inhibitory deficits and high levels of impulsivity across all stages of the disease, including euthymia. Methods: We tested how the inhibition of heuristics in favor of analytical strategies influences the elaboration of sentences with logical quantifiers by means of a sentence-picture matching task in which the processing of quantified sentences containing the logical universal and particular quantifiers was required. Behavioral and brain oscillatory responses were assessed employing EEG recordings. Results: In Experiment 1, in a group of healthy volunteers, we demonstrated how the presence of a universal quantifier generates an inhibition, characterized by a high cognitive load, which is resolved at the expense of a poorer behavioral performance compared to a lower cognitive load and neutral control task. In Experiment 2, comparing healthy adults and BD patients, EEG time-frequency analysis showed a different modulation of the theta frequency band localized centrally in the medial frontal areas and representative of the different degrees of cognitive control between groups. Limitations: Electrophysiological description should be interpreted with caution in light of the high signal-to-noise ratio determined by the complexity of the task. Conclusions: Even in euthymia, BD limited availability of resources for cognitive inhibition impacts the functionality of a fronto-parietal cortical network, responsible for cognitive control, and orchestrated by the activity of frontal areas synchronized in theta and beta frequency.
Inhibitory control in Bipolar Disorder disclosed by theta band modulation
Bertoli, Massimo;Zappasodi, Filippo;Croce, Pierpaolo;De Iure, Danilo;Pettorruso, Mauro;Cavallotto, Clara;Martinotti, Giovanni;Di Matteo, Rosalia;Brunetti, Marcella
2025-01-01
Abstract
Background: Cognitive inhibition is key to cognitive control in healthy and psychiatric conditions. Bipolar Disorder (BD) individuals display a range of inhibitory deficits and high levels of impulsivity across all stages of the disease, including euthymia. Methods: We tested how the inhibition of heuristics in favor of analytical strategies influences the elaboration of sentences with logical quantifiers by means of a sentence-picture matching task in which the processing of quantified sentences containing the logical universal and particular quantifiers was required. Behavioral and brain oscillatory responses were assessed employing EEG recordings. Results: In Experiment 1, in a group of healthy volunteers, we demonstrated how the presence of a universal quantifier generates an inhibition, characterized by a high cognitive load, which is resolved at the expense of a poorer behavioral performance compared to a lower cognitive load and neutral control task. In Experiment 2, comparing healthy adults and BD patients, EEG time-frequency analysis showed a different modulation of the theta frequency band localized centrally in the medial frontal areas and representative of the different degrees of cognitive control between groups. Limitations: Electrophysiological description should be interpreted with caution in light of the high signal-to-noise ratio determined by the complexity of the task. Conclusions: Even in euthymia, BD limited availability of resources for cognitive inhibition impacts the functionality of a fronto-parietal cortical network, responsible for cognitive control, and orchestrated by the activity of frontal areas synchronized in theta and beta frequency.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
