IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
EU - Europa 3.717
NA - Nord America 3.676
AS - Asia 1.785
Continente sconosciuto - Info sul continente non disponibili 7
SA - Sud America 3
OC - Oceania 2
AF - Africa 1
Totale 9.191
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Nazione #
US - Stati Uniti d'America 3.663
CN - Cina 761
UA - Ucraina 694
IE - Irlanda 571
IT - Italia 545
SE - Svezia 487
GB - Regno Unito 467
TR - Turchia 414
FR - Francia 413
SG - Singapore 362
DE - Germania 237
IN - India 198
FI - Finlandia 144
RU - Federazione Russa 91
IR - Iran 22
PL - Polonia 21
VN - Vietnam 18
BE - Belgio 12
GR - Grecia 12
CA - Canada 9
CZ - Repubblica Ceca 8
EU - Europa 7
IL - Israele 5
CH - Svizzera 4
NL - Olanda 3
AU - Australia 2
CL - Cile 2
ES - Italia 2
HU - Ungheria 2
KR - Corea 2
MX - Messico 2
AR - Argentina 1
AT - Austria 1
EG - Egitto 1
HK - Hong Kong 1
HR - Croazia 1
JM - Giamaica 1
JP - Giappone 1
LT - Lituania 1
PA - Panama 1
SM - San Marino 1
TH - Thailandia 1
Totale 9.191
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Città #
Chandler 767
Jacksonville 730
Dublin 563
Southend 394
Singapore 314
Princeton 244
Izmir 218
Nanjing 217
Dearborn 196
Cambridge 124
Chieti 117
Beijing 107
Wilmington 101
Ashburn 99
New York 86
Nanchang 76
Boardman 71
Santa Clara 67
Ann Arbor 62
Altamura 60
Shenyang 56
Woodbridge 44
Hebei 43
Kunming 38
Tianjin 36
Munich 32
Los Angeles 31
Rome 28
Jiaxing 23
Norwalk 23
Helsinki 22
Changsha 21
Jinan 21
Grevenbroich 20
Ardabil 19
Dong Ket 18
Kraków 18
Pescara 18
Hangzhou 17
Kocaeli 17
Düsseldorf 16
Seattle 15
Washington 15
Auburn Hills 14
Ningbo 14
Orange 14
Moscow 12
Brussels 10
Guangzhou 10
Leawood 10
Zhengzhou 10
Augusta 9
Collecorvino 9
Houston 9
Brno 8
Lanzhou 8
San Mateo 8
Changchun 7
Florence 7
Hefei 7
Romola 7
Taizhou 7
Chicago 6
Milan 6
Mumbai 6
Naples 6
Shanghai 6
Teramo 6
Bari 5
Bonn 5
Falls Church 5
Fuzhou 5
Haikou 5
Simi Valley 5
Elice 4
Messina 4
Silvi 4
Andover 3
Brescia 3
Fairport 3
Monmouth Junction 3
Ottawa 3
Palermo 3
Perugia 3
Rovato 3
Rovereto 3
Toronto 3
Trieste 3
Bangalore 2
Bonate Sotto 2
Bussolengo 2
Cedar Knolls 2
Cepagatti 2
Chengdu 2
Clifton 2
Dallas 2
Fairfield 2
Farindola 2
Fiume Veneto 2
Geneva 2
Totale 5.519
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Nome #
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 244
Synthesis of a novel TRH-related sulphonamido peptide 115
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 110
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 108
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 108
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 105
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 104
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 103
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 100
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 98
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 96
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 96
2,5-Diketopiperazines as neuroprotective agents 95
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 95
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 94
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 94
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 93
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 93
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 93
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 92
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 92
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 92
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 91
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 90
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 90
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 89
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 88
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 87
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 86
Synthesis and activity of novel TRH analogues targeted to TRH-R2 85
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 85
GPE and GPE analogues as promising neuroprotective agents 84
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 84
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 83
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 83
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 82
Hypotaurine disproportionation reaction: identification of products 81
Sintesi e conformazione di pseudopeptidi 81
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 81
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 80
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 80
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 80
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 79
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 78
Design and synthesis of glutathione analogues 77
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 77
N-acylamino derivatives related to the peptide portion of ergopeptines 77
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 77
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 77
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 77
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 77
Novel cyclic biphalin analogue with improved antinociceptive properties 77
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 77
Backbone-modified glutathione analogues 76
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 76
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 76
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 76
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 75
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 75
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 75
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 74
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 74
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 74
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 74
Synthesis of GPE analogues as potential neuroprotective agents 74
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 73
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 73
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 72
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 72
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 72
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 72
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 72
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 71
Prodrug approach for increasing cellular glutathione levels 71
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 71
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 71
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 71
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 71
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 70
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 69
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 69
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 69
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 68
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 68
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 68
Peptidic alfa-acylimino derivatives. Synthesis, properties and intramolecular interactions 68
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 67
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 67
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 66
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 66
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 65
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 65
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 65
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 65
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 64
psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine. 64
SYNTHESIS OF (S)-5,6-DIBROMO-TRYPTOPHAN DERIVATIVES AS BUILDING BLOCKS FOR PEPTIDE CHEMISTRY 64
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 64
Synthesys and evaluation of new endomorphin analogues modified at the Pro2 residue 63
Synthesis and biological evaluation of oligopeptides with antioxidant activity useful for treatment of neurodegenerative diseases 63
Totale 8.148
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Categoria #
all - tutte 34.995
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 34.995
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.004 0 0 0 0 117 162 258 165 23 123 150 6
2020/2021804 128 1 125 6 88 149 9 5 39 132 77 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/2025777 109 313 284 49 22 0 0 0 0 0 0 0
Totale 9.305