IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
EU - Europa 3.781
NA - Nord America 3.699
AS - Asia 1.855
Continente sconosciuto - Info sul continente non disponibili 7
SA - Sud America 3
OC - Oceania 2
AF - Africa 1
Totale 9.348
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Nazione #
US - Stati Uniti d'America 3.679
CN - Cina 765
UA - Ucraina 694
IT - Italia 572
IE - Irlanda 571
SE - Svezia 487
GB - Regno Unito 476
SG - Singapore 427
FR - Francia 415
TR - Turchia 414
DE - Germania 240
IN - India 198
FI - Finlandia 146
RU - Federazione Russa 91
BE - Belgio 24
IR - Iran 22
PL - Polonia 21
VN - Vietnam 18
CA - Canada 16
GR - Grecia 12
CZ - Repubblica Ceca 9
EU - Europa 7
LT - Lituania 7
IL - Israele 5
NL - Olanda 5
CH - Svizzera 4
AU - Australia 2
CL - Cile 2
ES - Italia 2
HU - Ungheria 2
KR - Corea 2
MX - Messico 2
AR - Argentina 1
AT - Austria 1
EG - Egitto 1
HK - Hong Kong 1
HR - Croazia 1
JM - Giamaica 1
JP - Giappone 1
PA - Panama 1
PH - Filippine 1
SM - San Marino 1
TH - Thailandia 1
Totale 9.348
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Città #
Chandler 767
Jacksonville 730
Dublin 563
Southend 394
Singapore 368
Princeton 244
Izmir 218
Nanjing 217
Dearborn 196
Cambridge 124
Chieti 117
Beijing 107
Ashburn 101
Wilmington 101
New York 86
Nanchang 76
Boardman 71
Santa Clara 67
Ann Arbor 62
Altamura 60
Shenyang 56
Woodbridge 44
Hebei 43
Kunming 38
Tianjin 36
Rome 33
Munich 32
Los Angeles 31
Helsinki 24
Jiaxing 23
Norwalk 23
Brussels 22
Changsha 21
Jinan 21
Grevenbroich 20
Ardabil 19
Pescara 19
Dong Ket 18
Kraków 18
Hangzhou 17
Kocaeli 17
Düsseldorf 16
Seattle 15
Washington 15
Auburn Hills 14
Ningbo 14
Orange 14
Moscow 12
Guangzhou 10
Leawood 10
Zhengzhou 10
Augusta 9
Collecorvino 9
Houston 9
Brno 8
Lanzhou 8
San Mateo 8
Changchun 7
Florence 7
Hefei 7
Romola 7
Shanghai 7
Taizhou 7
Toronto 7
Chicago 6
Fuzhou 6
Milan 6
Mumbai 6
Naples 6
Ottawa 6
Teramo 6
Bari 5
Bonn 5
Falls Church 5
Haikou 5
London 5
Perugia 5
Simi Valley 5
Elice 4
Genoa 4
Messina 4
Silvi 4
Treviso 4
Andover 3
Brescia 3
Fairport 3
Frankfurt am Main 3
Monmouth Junction 3
Palermo 3
Rovato 3
Rovereto 3
Trieste 3
Bangalore 2
Bonate Sotto 2
Bussolengo 2
Catania 2
Cedar Knolls 2
Cepagatti 2
Chengdu 2
Clifton 2
Totale 5.614
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Nome #
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 267
Synthesis of a novel TRH-related sulphonamido peptide 115
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 110
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 109
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 108
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 107
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 105
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 105
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 102
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 98
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 98
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 98
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 97
2,5-Diketopiperazines as neuroprotective agents 96
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 95
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 95
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 94
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 94
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 94
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 94
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 94
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 92
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 92
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 91
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 91
GPE and GPE analogues as promising neuroprotective agents 91
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 91
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 89
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 88
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 88
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 87
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 86
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 85
Synthesis and activity of novel TRH analogues targeted to TRH-R2 85
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 85
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 83
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 83
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 83
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 82
Hypotaurine disproportionation reaction: identification of products 81
Sintesi e conformazione di pseudopeptidi 81
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 81
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 80
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 80
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 80
Design and synthesis of glutathione analogues 79
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 79
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 79
Novel cyclic biphalin analogue with improved antinociceptive properties 79
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 79
N-acylamino derivatives related to the peptide portion of ergopeptines 78
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 78
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 78
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 77
Backbone-modified glutathione analogues 77
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 77
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 77
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 77
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 76
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 76
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 76
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 76
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 75
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 75
Synthesis of GPE analogues as potential neuroprotective agents 75
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 74
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 74
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 74
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 74
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 74
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 73
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 73
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 73
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 73
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 72
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 72
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 71
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 71
Prodrug approach for increasing cellular glutathione levels 71
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 70
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 70
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 69
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 69
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 69
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 69
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 68
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 68
Peptidic alfa-acylimino derivatives. Synthesis, properties and intramolecular interactions 68
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 67
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 67
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 67
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 67
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 66
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 66
Synthesis and biological evaluation of oligopeptides with antioxidant activity useful for treatment of neurodegenerative diseases 65
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 65
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 64
psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine. 64
Synthesys and evaluation of new endomorphin analogues modified at the Pro2 residue 64
SYNTHESIS OF (S)-5,6-DIBROMO-TRYPTOPHAN DERIVATIVES AS BUILDING BLOCKS FOR PEPTIDE CHEMISTRY 64
Totale 8.298
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Categoria #
all - tutte 37.216
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.216
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020725 0 0 0 0 0 0 258 165 23 123 150 6
2020/2021804 128 1 125 6 88 149 9 5 39 132 77 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/2025934 109 313 284 49 24 125 30 0 0 0 0 0
Totale 9.462