IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
EU - Europa 5.756
NA - Nord America 5.581
AS - Asia 3.764
SA - Sud America 290
AF - Africa 56
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 5
Totale 15.459
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 5.483
RU - Federazione Russa 1.698
SG - Singapore 1.347
CN - Cina 1.195
UA - Ucraina 697
IT - Italia 647
IE - Irlanda 572
GB - Regno Unito 538
SE - Svezia 498
FR - Francia 458
TR - Turchia 431
DE - Germania 307
VN - Vietnam 294
IN - India 261
BR - Brasile 243
FI - Finlandia 162
PL - Polonia 56
CA - Canada 52
HK - Hong Kong 36
BD - Bangladesh 30
KR - Corea 30
MX - Messico 30
BE - Belgio 26
JP - Giappone 25
NL - Olanda 25
ES - Italia 23
ZA - Sudafrica 23
IR - Iran 22
AR - Argentina 20
IQ - Iraq 14
GR - Grecia 13
CZ - Repubblica Ceca 11
LT - Lituania 11
SA - Arabia Saudita 10
IL - Israele 9
ID - Indonesia 8
EU - Europa 7
KE - Kenya 7
MA - Marocco 7
PH - Filippine 7
PK - Pakistan 7
UZ - Uzbekistan 7
AU - Australia 5
CL - Cile 5
CO - Colombia 5
EC - Ecuador 5
EG - Egitto 5
MY - Malesia 5
TN - Tunisia 5
CH - Svizzera 4
JM - Giamaica 4
JO - Giordania 4
VE - Venezuela 4
AE - Emirati Arabi Uniti 3
BO - Bolivia 3
KZ - Kazakistan 3
LB - Libano 3
NI - Nicaragua 3
AO - Angola 2
AZ - Azerbaigian 2
CR - Costa Rica 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
EE - Estonia 2
HU - Ungheria 2
KW - Kuwait 2
PA - Panama 2
PY - Paraguay 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
UY - Uruguay 2
AL - Albania 1
AM - Armenia 1
AT - Austria 1
BH - Bahrain 1
BY - Bielorussia 1
CG - Congo 1
ET - Etiopia 1
GA - Gabon 1
GD - Grenada 1
HR - Croazia 1
LA - Repubblica Popolare Democratica del Laos 1
NG - Nigeria 1
NO - Norvegia 1
OM - Oman 1
PE - Perù 1
PS - Palestinian Territory 1
SM - San Marino 1
SV - El Salvador 1
TT - Trinidad e Tobago 1
UG - Uganda 1
Totale 15.459
Salva come PNG Salva come JPEG
Città #
Singapore 1.020
Chandler 767
Jacksonville 731
Dublin 564
San Jose 535
Southend 394
Ashburn 314
Beijing 254
Princeton 244
Dallas 237
Izmir 219
Nanjing 217
Dearborn 196
Los Angeles 139
New York 135
Cambridge 124
Chieti 118
Tongling 104
Wilmington 101
Ho Chi Minh City 93
Munich 81
Santa Clara 80
Nanchang 76
The Dalles 73
Boardman 71
Ann Arbor 62
Hanoi 61
Altamura 60
Moscow 57
Shenyang 56
Buffalo 54
Woodbridge 44
Hebei 43
Rome 43
Kunming 38
Tianjin 36
Hefei 34
Hong Kong 32
Seoul 28
Warsaw 28
Helsinki 27
São Paulo 27
Chennai 25
Tokyo 24
Jiaxing 23
Norwalk 23
Brussels 22
Denver 22
Changsha 21
Jinan 21
Chicago 20
Grevenbroich 20
Houston 20
Johannesburg 20
Orem 20
Seattle 20
Ardabil 19
Pescara 19
Redondo Beach 19
Boston 18
Dong Ket 18
Kraków 18
Brooklyn 17
Frankfurt am Main 17
Hangzhou 17
Kocaeli 17
Montreal 17
San Francisco 17
Düsseldorf 16
Washington 16
Atlanta 15
London 15
Milan 15
Toronto 15
Auburn Hills 14
Haiphong 14
Ningbo 14
Orange 14
Poplar 14
Turku 13
Dhaka 12
Biên Hòa 11
Mumbai 11
Stockholm 11
Ankara 10
Da Nang 10
Guangzhou 10
Leawood 10
Mexico City 10
Phoenix 10
Zhengzhou 10
Augusta 9
Bexley 9
Collecorvino 9
New Delhi 9
Belo Horizonte 8
Brno 8
Lanzhou 8
San Mateo 8
Shanghai 8
Totale 8.497
Salva come PNG Salva come JPEG
Nome #
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 768
Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudopeptides 743
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 394
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 191
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 169
2,5-Diketopiperazines as neuroprotective agents 168
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 155
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 154
Synthesis of a novel TRH-related sulphonamido peptide 153
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 153
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 152
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 149
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 148
GPE and GPE analogues as promising neuroprotective agents 147
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 146
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 146
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 145
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 143
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 141
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 141
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 140
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 139
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 138
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 136
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 135
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 134
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 133
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 133
Synthesis and activity of novel TRH analogues targeted to TRH-R2 131
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 131
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 131
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 131
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 130
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 130
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 130
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 128
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 128
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 127
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 125
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 125
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 124
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 124
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 123
Design and synthesis of glutathione analogues 123
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 123
Backbone-modified glutathione analogues 123
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 123
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 122
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 121
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 121
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 120
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 120
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 120
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 119
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 119
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 119
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 118
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 118
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 118
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 118
Novel cyclic biphalin analogue with improved antinociceptive properties 118
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 117
Hypotaurine disproportionation reaction: identification of products 115
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 115
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 115
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 115
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 115
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 114
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 114
N-acylamino derivatives related to the peptide portion of ergopeptines 112
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 112
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 111
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 111
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 111
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 109
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 109
Synthesis of GPE analogues as potential neuroprotective agents 109
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 108
cis-4-Amino-l-proline Residue As a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues: Part 2 108
Sintesi e conformazione di pseudopeptidi 107
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 107
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 107
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 107
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 106
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 105
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 105
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 103
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 103
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 103
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 103
Multifuctional L-Dopa Codrugs Containing Antioxidant Molecules 103
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 102
Prodrug approach for increasing cellular glutathione levels 102
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 102
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 100
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 99
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 95
Cyclization under mild conditions of salicyloyl-dipeptides 93
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 93
Psi(SO2-NH) transition state isosteres of peptides. Synthesis of the glutathione disulfide analogue [Glu-psi(SO2-NH)-Cys-Gly]2 92
Totale 13.832
Salva come PNG Salva come JPEG
Categoria #
all - tutte 56.884
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 56.884
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021254 0 0 0 0 0 0 0 0 0 132 77 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/20252.008 109 313 284 49 24 125 42 97 151 91 228 495
2025/20265.037 424 161 355 477 432 292 709 225 1.716 246 0 0
Totale 15.573