IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
NA - Nord America 4.793
EU - Europa 4.104
AS - Asia 3.154
SA - Sud America 238
AF - Africa 32
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 2
Totale 12.330
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Nazione #
US - Stati Uniti d'America 4.710
CN - Cina 1.148
SG - Singapore 1.108
UA - Ucraina 696
IT - Italia 632
IE - Irlanda 572
GB - Regno Unito 528
SE - Svezia 497
FR - Francia 454
TR - Turchia 426
DE - Germania 306
IN - India 234
BR - Brasile 212
FI - Finlandia 162
RU - Federazione Russa 92
VN - Vietnam 77
PL - Polonia 52
CA - Canada 50
KR - Corea 30
BE - Belgio 26
HK - Hong Kong 25
NL - Olanda 23
IR - Iran 22
JP - Giappone 21
ES - Italia 20
MX - Messico 20
BD - Bangladesh 19
ZA - Sudafrica 17
AR - Argentina 13
GR - Grecia 12
LT - Lituania 11
CZ - Repubblica Ceca 10
IL - Israele 8
IQ - Iraq 8
EU - Europa 7
MA - Marocco 6
SA - Arabia Saudita 6
EC - Ecuador 5
CH - Svizzera 4
ID - Indonesia 4
TN - Tunisia 4
CL - Cile 3
JM - Giamaica 3
PK - Pakistan 3
AU - Australia 2
CR - Costa Rica 2
DO - Repubblica Dominicana 2
EE - Estonia 2
HU - Ungheria 2
JO - Giordania 2
KE - Kenya 2
LB - Libano 2
NI - Nicaragua 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
UY - Uruguay 2
UZ - Uzbekistan 2
AE - Emirati Arabi Uniti 1
AM - Armenia 1
AT - Austria 1
CG - Congo 1
CO - Colombia 1
EG - Egitto 1
GD - Grenada 1
HR - Croazia 1
MY - Malesia 1
OM - Oman 1
PA - Panama 1
PE - Perù 1
PH - Filippine 1
PY - Paraguay 1
SM - San Marino 1
SV - El Salvador 1
TT - Trinidad e Tobago 1
UG - Uganda 1
Totale 12.330
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Città #
Singapore 816
Chandler 767
Jacksonville 731
Dublin 564
Southend 394
Beijing 251
Princeton 244
Ashburn 238
Dallas 234
Izmir 219
Nanjing 217
Dearborn 196
Los Angeles 133
New York 128
Cambridge 124
Chieti 118
Tongling 104
Wilmington 101
Munich 81
Nanchang 76
Santa Clara 75
The Dalles 73
Boardman 71
Ann Arbor 62
Altamura 60
Shenyang 56
Buffalo 54
Woodbridge 44
Hebei 43
Rome 42
Kunming 38
Tianjin 36
Hefei 34
Seoul 28
Helsinki 27
Hong Kong 25
Warsaw 24
Jiaxing 23
Norwalk 23
Brussels 22
Changsha 21
Jinan 21
Grevenbroich 20
Seattle 20
São Paulo 20
Tokyo 20
Ardabil 19
Chicago 19
Pescara 19
Redondo Beach 19
Boston 18
Dong Ket 18
Kraków 18
Denver 17
Hangzhou 17
Ho Chi Minh City 17
Kocaeli 17
Brooklyn 16
Düsseldorf 16
Frankfurt am Main 16
Johannesburg 16
Montreal 16
Washington 16
Chennai 15
Houston 15
London 15
San Francisco 15
Toronto 15
Auburn Hills 14
Milan 14
Ningbo 14
Orange 14
Hanoi 13
Turku 13
Moscow 12
Orem 12
Poplar 12
Mumbai 11
Atlanta 10
Guangzhou 10
Leawood 10
Stockholm 10
Zhengzhou 10
Ankara 9
Augusta 9
Bexley 9
Collecorvino 9
Mexico City 9
Phoenix 9
Brno 8
Lanzhou 8
San Mateo 8
Shanghai 8
Belo Horizonte 7
Changchun 7
Dhaka 7
Florence 7
Naples 7
New Delhi 7
Romola 7
Totale 7.401
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Nome #
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 363
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 167
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 151
Synthesis of a novel TRH-related sulphonamido peptide 141
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 134
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 134
2,5-Diketopiperazines as neuroprotective agents 134
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 133
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 132
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 131
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 131
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 130
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 128
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 127
GPE and GPE analogues as promising neuroprotective agents 127
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 127
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 126
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 124
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 123
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 122
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 122
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 120
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 118
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 118
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 116
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 116
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 114
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 114
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 114
Synthesis and activity of novel TRH analogues targeted to TRH-R2 113
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 113
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 113
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 113
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 112
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 111
Backbone-modified glutathione analogues 110
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 109
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 108
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 107
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 107
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 107
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 107
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 107
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 106
Novel cyclic biphalin analogue with improved antinociceptive properties 106
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 105
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 105
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 105
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 104
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 104
Design and synthesis of glutathione analogues 103
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 103
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 103
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 102
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 102
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 101
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 101
Hypotaurine disproportionation reaction: identification of products 100
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 100
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 100
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 100
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 100
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 100
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 99
Sintesi e conformazione di pseudopeptidi 98
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 98
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 98
N-acylamino derivatives related to the peptide portion of ergopeptines 97
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 97
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 97
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 97
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 96
Synthesis of GPE analogues as potential neuroprotective agents 96
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 96
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 96
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 95
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 94
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 94
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 93
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 93
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 93
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 92
Prodrug approach for increasing cellular glutathione levels 92
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 92
cis-4-Amino-l-proline Residue As a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues: Part 2 92
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 91
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 91
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 91
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 90
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 90
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 88
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 88
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 86
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 86
Multifuctional L-Dopa Codrugs Containing Antioxidant Molecules 85
Peptidic alfa-acylimino derivatives. Synthesis, properties and intramolecular interactions 84
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 83
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 83
SYNTHESIS OF (S)-5,6-DIBROMO-TRYPTOPHAN DERIVATIVES AS BUILDING BLOCKS FOR PEPTIDE CHEMISTRY 82
psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine. 81
Totale 10.918
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Categoria #
all - tutte 51.331
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.331
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021456 0 0 0 0 0 149 9 5 39 132 77 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/20252.008 109 313 284 49 24 125 42 97 151 91 228 495
2025/20261.908 424 161 355 477 432 59 0 0 0 0 0 0
Totale 12.444