IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
NA - Nord America 5.827
EU - Europa 5.772
AS - Asia 3.798
SA - Sud America 290
AF - Africa 56
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 5
Totale 15.755
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Nazione #
US - Stati Uniti d'America 5.722
RU - Federazione Russa 1.698
SG - Singapore 1.356
CN - Cina 1.199
UA - Ucraina 697
IT - Italia 663
IE - Irlanda 572
GB - Regno Unito 538
SE - Svezia 498
FR - Francia 458
TR - Turchia 431
DE - Germania 307
VN - Vietnam 294
IN - India 261
BR - Brasile 243
FI - Finlandia 162
CA - Canada 56
PL - Polonia 56
BD - Bangladesh 47
HK - Hong Kong 38
MX - Messico 31
KR - Corea 30
JP - Giappone 27
BE - Belgio 26
NL - Olanda 25
ES - Italia 23
ZA - Sudafrica 23
IR - Iran 22
AR - Argentina 20
IQ - Iraq 14
GR - Grecia 13
CZ - Repubblica Ceca 11
LT - Lituania 11
SA - Arabia Saudita 10
IL - Israele 9
ID - Indonesia 8
EU - Europa 7
KE - Kenya 7
MA - Marocco 7
PH - Filippine 7
PK - Pakistan 7
UZ - Uzbekistan 7
JM - Giamaica 6
AU - Australia 5
CL - Cile 5
CO - Colombia 5
EC - Ecuador 5
EG - Egitto 5
MY - Malesia 5
TN - Tunisia 5
CH - Svizzera 4
JO - Giordania 4
VE - Venezuela 4
AE - Emirati Arabi Uniti 3
BO - Bolivia 3
KZ - Kazakistan 3
LB - Libano 3
NI - Nicaragua 3
AO - Angola 2
AZ - Azerbaigian 2
CR - Costa Rica 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
EE - Estonia 2
HU - Ungheria 2
KW - Kuwait 2
PA - Panama 2
PY - Paraguay 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
UY - Uruguay 2
AL - Albania 1
AM - Armenia 1
AT - Austria 1
BH - Bahrain 1
BY - Bielorussia 1
CG - Congo 1
ET - Etiopia 1
GA - Gabon 1
GD - Grenada 1
HR - Croazia 1
LA - Repubblica Popolare Democratica del Laos 1
NG - Nigeria 1
NO - Norvegia 1
OM - Oman 1
PE - Perù 1
PS - Palestinian Territory 1
SM - San Marino 1
SV - El Salvador 1
TT - Trinidad e Tobago 1
UG - Uganda 1
Totale 15.755
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Città #
Singapore 1.023
Chandler 767
Jacksonville 731
San Jose 630
Dublin 564
Southend 394
Ashburn 320
Beijing 254
Princeton 244
Dallas 242
Izmir 219
Nanjing 217
Dearborn 196
Los Angeles 146
New York 138
Cambridge 124
Chieti 119
Tongling 104
Wilmington 101
Ho Chi Minh City 93
Santa Clara 88
Munich 81
Council Bluffs 76
Nanchang 76
The Dalles 73
Boardman 71
Ann Arbor 62
Hanoi 61
Altamura 60
Moscow 57
Buffalo 56
Shenyang 56
Woodbridge 44
Hebei 43
Rome 43
Kunming 38
Tianjin 36
Hefei 34
Hong Kong 34
Seoul 28
Warsaw 28
Helsinki 27
São Paulo 27
Chennai 25
Tokyo 25
Houston 23
Jiaxing 23
Norwalk 23
Brussels 22
Denver 22
Changsha 21
Chicago 21
Jinan 21
Grevenbroich 20
Johannesburg 20
Orem 20
Seattle 20
Ardabil 19
Pescara 19
Redondo Beach 19
Boston 18
Brooklyn 18
Dong Ket 18
Kraków 18
San Francisco 18
Frankfurt am Main 17
Hangzhou 17
Kocaeli 17
Montreal 17
Toronto 17
Düsseldorf 16
Washington 16
Atlanta 15
London 15
Milan 15
Auburn Hills 14
Haiphong 14
Ningbo 14
Orange 14
Poplar 14
Turku 13
Dhaka 12
Phoenix 12
Biên Hòa 11
Mexico City 11
Mumbai 11
Stockholm 11
Ankara 10
Da Nang 10
Guangzhou 10
Leawood 10
Zhengzhou 10
Augusta 9
Bexley 9
Collecorvino 9
New Delhi 9
Belo Horizonte 8
Brno 8
Florence 8
Lanzhou 8
Totale 8.709
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Nome #
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 769
Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudopeptides 747
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 403
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 197
2,5-Diketopiperazines as neuroprotective agents 188
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 174
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 160
Synthesis of a novel TRH-related sulphonamido peptide 157
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 156
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 156
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 154
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 153
GPE and GPE analogues as promising neuroprotective agents 153
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 152
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 149
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 147
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 146
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 146
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 143
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 141
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 140
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 139
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 139
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 139
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 137
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 136
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 136
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 135
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 134
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 133
Synthesis and activity of novel TRH analogues targeted to TRH-R2 132
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 132
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 131
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 131
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 130
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 130
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 130
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 129
Hypotaurine disproportionation reaction: identification of products 128
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 128
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 126
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 126
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 126
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 126
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 125
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 125
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 125
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 125
Design and synthesis of glutathione analogues 124
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 124
Backbone-modified glutathione analogues 124
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 124
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 124
Novel cyclic biphalin analogue with improved antinociceptive properties 124
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 123
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 123
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 123
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 122
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 121
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 121
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 120
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 120
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 119
N-acylamino derivatives related to the peptide portion of ergopeptines 117
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 117
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 116
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 116
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 116
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 115
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 115
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 115
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 115
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 113
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 112
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 112
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 112
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 111
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 111
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 109
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 109
Synthesis of GPE analogues as potential neuroprotective agents 109
cis-4-Amino-l-proline Residue As a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues: Part 2 109
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 108
Sintesi e conformazione di pseudopeptidi 107
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 107
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 105
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 105
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 104
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 104
Multifuctional L-Dopa Codrugs Containing Antioxidant Molecules 104
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 104
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 103
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 103
Prodrug approach for increasing cellular glutathione levels 103
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 101
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 99
Cyclization under mild conditions of salicyloyl-dipeptides 98
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 96
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 96
Phosphoproteomic analysis of the effect of cyclo(His-Pro) dipeptide on PC12 cells 93
Totale 14.089
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Categoria #
all - tutte 60.550
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.550
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202145 0 0 0 0 0 0 0 0 0 0 0 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/20252.008 109 313 284 49 24 125 42 97 151 91 228 495
2025/20265.333 424 161 355 477 432 292 709 225 1.716 320 182 40
Totale 15.869