IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
NA - Nord America 6.903
EU - Europa 5.892
AS - Asia 3.847
SA - Sud America 316
Continente sconosciuto - Info sul continente non disponibili 126
AF - Africa 63
OC - Oceania 5
Totale 17.152
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Nazione #
US - Stati Uniti d'America 6.717
RU - Federazione Russa 1.717
SG - Singapore 1.362
CN - Cina 1.210
IT - Italia 734
UA - Ucraina 701
IE - Irlanda 573
GB - Regno Unito 549
SE - Svezia 499
FR - Francia 459
TR - Turchia 431
DE - Germania 310
VN - Vietnam 295
IN - India 262
BR - Brasile 250
FI - Finlandia 162
CA - Canada 83
PL - Polonia 59
BD - Bangladesh 50
HK - Hong Kong 41
MX - Messico 33
KR - Corea 30
JP - Giappone 28
NL - Olanda 27
BE - Belgio 26
ES - Italia 25
AR - Argentina 23
ZA - Sudafrica 23
IR - Iran 22
IL - Israele 20
CO - Colombia 14
IQ - Iraq 14
GR - Grecia 13
CZ - Repubblica Ceca 11
GT - Guatemala 11
ID - Indonesia 11
JM - Giamaica 11
LT - Lituania 11
PH - Filippine 11
SA - Arabia Saudita 11
TT - Trinidad e Tobago 10
CR - Costa Rica 9
EC - Ecuador 9
PK - Pakistan 8
EU - Europa 7
HN - Honduras 7
KE - Kenya 7
MA - Marocco 7
SC - Seychelles 7
UZ - Uzbekistan 7
MY - Malesia 6
SV - El Salvador 6
VE - Venezuela 6
AU - Australia 5
CL - Cile 5
EG - Egitto 5
NI - Nicaragua 5
TN - Tunisia 5
CH - Svizzera 4
CW - ???statistics.table.value.countryCode.CW??? 4
JO - Giordania 4
PR - Porto Rico 4
AE - Emirati Arabi Uniti 3
BO - Bolivia 3
KZ - Kazakistan 3
LB - Libano 3
UY - Uruguay 3
AO - Angola 2
AZ - Azerbaigian 2
BH - Bahrain 2
BY - Bielorussia 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
EE - Estonia 2
HU - Ungheria 2
KW - Kuwait 2
PA - Panama 2
PY - Paraguay 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
AL - Albania 1
AM - Armenia 1
AT - Austria 1
CG - Congo 1
ET - Etiopia 1
GA - Gabon 1
GD - Grenada 1
GP - Guadalupe 1
HR - Croazia 1
KN - Saint Kitts e Nevis 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
NG - Nigeria 1
NO - Norvegia 1
NP - Nepal 1
OM - Oman 1
PE - Perù 1
PS - Palestinian Territory 1
SM - San Marino 1
UG - Uganda 1
Totale 17.037
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Città #
Singapore 1.027
Chandler 769
Jacksonville 731
San Jose 690
Dublin 565
Southend 394
Ashburn 370
Beijing 257
Dallas 246
Princeton 244
Izmir 219
Nanjing 217
Council Bluffs 204
Dearborn 196
Los Angeles 158
New York 141
Cambridge 124
Chieti 121
Santa Clara 110
Tongling 104
Wilmington 101
Ho Chi Minh City 94
Munich 81
Nanchang 76
The Dalles 73
Boardman 71
Washington 70
Buffalo 63
Ann Arbor 62
Hanoi 61
Altamura 60
Moscow 57
Shenyang 56
Rome 50
Columbus 46
Woodbridge 44
Hebei 43
Kunming 38
Hong Kong 37
Tianjin 36
Hefei 34
Brooklyn 29
Chicago 29
Houston 29
Seoul 28
Warsaw 28
Helsinki 27
São Paulo 27
Tokyo 26
Chennai 25
Denver 25
Kimball 25
Jiaxing 23
Norwalk 23
Brussels 22
Seattle 22
Changsha 21
Jinan 21
Phoenix 21
Grevenbroich 20
Johannesburg 20
Milan 20
Montreal 20
Orem 20
Pescara 20
Ardabil 19
Redondo Beach 19
Toronto 19
Boston 18
Dong Ket 18
Frankfurt am Main 18
Kraków 18
San Francisco 18
Atlanta 17
Hangzhou 17
Kocaeli 17
Düsseldorf 16
Philadelphia 16
London 15
North Bergen 15
Auburn Hills 14
Haiphong 14
Kansas City 14
Ningbo 14
Orange 14
Poplar 14
Turku 13
Dhaka 12
Biên Hòa 11
Mexico City 11
Mumbai 11
Stockholm 11
Ankara 10
Da Nang 10
Florence 10
Guangzhou 10
Leawood 10
Zhengzhou 10
Augusta 9
Bexley 9
Totale 9.202
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Nome #
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 781
Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudopeptides 757
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 414
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 219
2,5-Diketopiperazines as neuroprotective agents 203
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 185
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 177
Synthesis of a novel TRH-related sulphonamido peptide 171
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 171
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 169
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 168
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 166
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 164
GPE and GPE analogues as promising neuroprotective agents 164
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 163
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 157
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 154
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 152
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 151
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 151
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 151
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 150
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 150
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 148
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 147
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 147
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 147
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 145
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 145
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 144
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 143
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 143
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 143
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 142
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 142
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 142
Synthesis and activity of novel TRH analogues targeted to TRH-R2 141
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 140
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 140
Hypotaurine disproportionation reaction: identification of products 139
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 139
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 138
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 138
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 137
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 137
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 137
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 136
Design and synthesis of glutathione analogues 135
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 135
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 134
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 134
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 134
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 134
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 133
Backbone-modified glutathione analogues 133
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 133
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 132
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 132
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 131
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 131
Novel cyclic biphalin analogue with improved antinociceptive properties 131
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 131
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 129
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 129
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 128
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 128
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 127
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 127
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 127
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 126
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 125
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 124
N-acylamino derivatives related to the peptide portion of ergopeptines 123
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 122
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 122
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 121
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 121
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 121
cis-4-Amino-l-proline Residue As a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues: Part 2 121
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 119
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 119
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 118
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 118
Sintesi e conformazione di pseudopeptidi 116
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 116
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 115
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 115
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 115
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 114
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 114
Synthesis of GPE analogues as potential neuroprotective agents 114
Prodrug approach for increasing cellular glutathione levels 113
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 112
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 111
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 110
Cyclization under mild conditions of salicyloyl-dipeptides 109
New potent caspase-3 inhibitors as anti-apoptotic agents 109
Multifuctional L-Dopa Codrugs Containing Antioxidant Molecules 109
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 107
Phosphoproteomic analysis of the effect of cyclo(His-Pro) dipeptide on PC12 cells 104
Totale 15.179
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Categoria #
all - tutte 67.355
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 67.355
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022396 0 0 0 0 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/20252.008 109 313 284 49 24 125 42 97 151 91 228 495
2025/20265.344 424 161 355 477 432 292 709 225 1.716 320 182 51
2026/20271.272 82 232 132 638 188 0 0 0 0 0 0 0
Totale 17.152