IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
EU - Europa 3.985
NA - Nord America 3.949
AS - Asia 2.450
SA - Sud America 184
AF - Africa 15
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 2
Totale 10.592
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Nazione #
US - Stati Uniti d'America 3.906
CN - Cina 869
SG - Singapore 839
UA - Ucraina 695
IT - Italia 613
IE - Irlanda 572
GB - Regno Unito 495
SE - Svezia 489
FR - Francia 453
TR - Turchia 418
DE - Germania 305
IN - India 209
BR - Brasile 166
FI - Finlandia 152
RU - Federazione Russa 91
PL - Polonia 32
BE - Belgio 26
CA - Canada 25
IR - Iran 22
HK - Hong Kong 20
VN - Vietnam 19
NL - Olanda 18
BD - Bangladesh 13
GR - Grecia 12
CZ - Repubblica Ceca 9
LT - Lituania 9
MX - Messico 9
IL - Israele 8
JP - Giappone 8
EU - Europa 7
AR - Argentina 6
IQ - Iraq 6
MA - Marocco 5
SA - Arabia Saudita 5
CH - Svizzera 4
EC - Ecuador 4
ES - Italia 4
CL - Cile 3
ZA - Sudafrica 3
AU - Australia 2
HU - Ungheria 2
JM - Giamaica 2
KE - Kenya 2
KR - Corea 2
NI - Nicaragua 2
PK - Pakistan 2
SY - Repubblica araba siriana 2
TN - Tunisia 2
UY - Uruguay 2
UZ - Uzbekistan 2
AE - Emirati Arabi Uniti 1
AM - Armenia 1
AT - Austria 1
CG - Congo 1
CO - Colombia 1
DO - Repubblica Dominicana 1
EE - Estonia 1
EG - Egitto 1
GD - Grenada 1
HR - Croazia 1
JO - Giordania 1
LB - Libano 1
PA - Panama 1
PE - Perù 1
PH - Filippine 1
PY - Paraguay 1
SM - San Marino 1
SV - El Salvador 1
TH - Thailandia 1
TT - Trinidad e Tobago 1
UG - Uganda 1
Totale 10.592
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Città #
Chandler 767
Jacksonville 730
Singapore 649
Dublin 564
Southend 394
Princeton 244
Izmir 219
Nanjing 217
Dearborn 196
Cambridge 124
Chieti 117
Beijing 107
Ashburn 106
Tongling 104
Wilmington 101
New York 93
Munich 81
Nanchang 76
The Dalles 73
Boardman 71
Santa Clara 68
Ann Arbor 62
Altamura 60
Shenyang 56
Woodbridge 44
Hebei 43
Los Angeles 40
Kunming 38
Rome 38
Tianjin 36
Helsinki 24
Jiaxing 23
Norwalk 23
Brussels 22
Changsha 21
Jinan 21
Grevenbroich 20
Hong Kong 20
Ardabil 19
Pescara 19
Dong Ket 18
Kraków 18
Hangzhou 17
Kocaeli 17
Seattle 17
Düsseldorf 16
Frankfurt am Main 16
Washington 15
Auburn Hills 14
Ningbo 14
Orange 14
Moscow 12
Chicago 11
San Francisco 11
Guangzhou 10
Leawood 10
Zhengzhou 10
Augusta 9
Bexley 9
Collecorvino 9
Houston 9
London 9
São Paulo 9
Toronto 9
Brno 8
Dallas 8
Lanzhou 8
Milan 8
San Mateo 8
Boston 7
Changchun 7
Florence 7
Hefei 7
Naples 7
Romola 7
Roubaix 7
Shanghai 7
Taizhou 7
Tokyo 7
Wroclaw 7
Brooklyn 6
Dhaka 6
Fuzhou 6
Mumbai 6
Ottawa 6
Rio de Janeiro 6
Teramo 6
Turku 6
Bari 5
Belo Horizonte 5
Bonn 5
Falls Church 5
Haikou 5
Perugia 5
Simi Valley 5
Warsaw 5
Campinas 4
Columbus 4
Curitiba 4
Elice 4
Totale 6.254
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Nome #
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 328
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 128
Synthesis of a novel TRH-related sulphonamido peptide 125
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 124
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 120
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 120
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 116
2,5-Diketopiperazines as neuroprotective agents 116
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 116
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 114
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 112
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 112
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 111
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 110
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 108
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 108
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 107
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 106
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 106
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 106
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 105
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 104
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 103
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 102
GPE and GPE analogues as promising neuroprotective agents 101
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 101
Synthesis and activity of novel TRH analogues targeted to TRH-R2 100
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 99
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 98
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 98
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 98
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 98
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 98
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 96
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 94
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 94
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 94
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 93
Design and synthesis of glutathione analogues 92
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 92
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 92
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 92
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 91
Backbone-modified glutathione analogues 91
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 91
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 91
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 91
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 91
Hypotaurine disproportionation reaction: identification of products 89
Sintesi e conformazione di pseudopeptidi 89
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 89
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 89
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 89
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 88
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 87
Synthesis of GPE analogues as potential neuroprotective agents 87
Novel cyclic biphalin analogue with improved antinociceptive properties 87
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 86
N-acylamino derivatives related to the peptide portion of ergopeptines 85
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 85
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 85
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 84
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 84
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 83
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 83
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 83
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 83
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 83
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 83
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 83
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 82
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 82
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 82
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 81
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 81
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 81
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 81
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 81
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 81
Prodrug approach for increasing cellular glutathione levels 80
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 79
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 79
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 77
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 77
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 77
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 77
Peptidic alfa-acylimino derivatives. Synthesis, properties and intramolecular interactions 76
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 75
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 75
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 75
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 75
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 75
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 75
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 74
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 74
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 73
psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine. 72
SYNTHESIS OF (S)-5,6-DIBROMO-TRYPTOPHAN DERIVATIVES AS BUILDING BLOCKS FOR PEPTIDE CHEMISTRY 71
Synthesis and biological evaluation of oligopeptides with antioxidant activity useful for treatment of neurodegenerative diseases 70
Identification of an oxidation product of aminoethylcysteine ketimine dimer 70
Totale 9.375
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Categoria #
all - tutte 44.893
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.893
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021804 128 1 125 6 88 149 9 5 39 132 77 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/20252.008 109 313 284 49 24 125 42 97 151 91 228 495
2025/2026170 170 0 0 0 0 0 0 0 0 0 0 0
Totale 10.706