IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
NA - Nord America 6.116
EU - Europa 5.801
AS - Asia 3.827
SA - Sud America 313
Continente sconosciuto - Info sul continente non disponibili 121
AF - Africa 56
OC - Oceania 5
Totale 16.239
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Nazione #
US - Stati Uniti d'America 6.002
RU - Federazione Russa 1.698
SG - Singapore 1.362
CN - Cina 1.207
UA - Ucraina 699
IT - Italia 683
IE - Irlanda 572
GB - Regno Unito 539
SE - Svezia 498
FR - Francia 459
TR - Turchia 431
DE - Germania 309
VN - Vietnam 295
IN - India 261
BR - Brasile 250
FI - Finlandia 162
CA - Canada 60
PL - Polonia 57
BD - Bangladesh 49
HK - Hong Kong 41
MX - Messico 31
KR - Corea 30
JP - Giappone 27
BE - Belgio 26
NL - Olanda 25
AR - Argentina 23
ES - Italia 23
ZA - Sudafrica 23
IR - Iran 22
IQ - Iraq 14
CO - Colombia 13
GR - Grecia 13
CZ - Repubblica Ceca 11
ID - Indonesia 11
LT - Lituania 11
SA - Arabia Saudita 11
IL - Israele 9
PH - Filippine 8
PK - Pakistan 8
EC - Ecuador 7
EU - Europa 7
JM - Giamaica 7
KE - Kenya 7
MA - Marocco 7
UZ - Uzbekistan 7
MY - Malesia 6
VE - Venezuela 6
AU - Australia 5
CL - Cile 5
EG - Egitto 5
TN - Tunisia 5
CH - Svizzera 4
JO - Giordania 4
AE - Emirati Arabi Uniti 3
BO - Bolivia 3
KZ - Kazakistan 3
LB - Libano 3
NI - Nicaragua 3
UY - Uruguay 3
AO - Angola 2
AZ - Azerbaigian 2
BH - Bahrain 2
BY - Bielorussia 2
CR - Costa Rica 2
DO - Repubblica Dominicana 2
DZ - Algeria 2
EE - Estonia 2
HN - Honduras 2
HU - Ungheria 2
KW - Kuwait 2
PA - Panama 2
PY - Paraguay 2
SV - El Salvador 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
AL - Albania 1
AM - Armenia 1
AT - Austria 1
CG - Congo 1
ET - Etiopia 1
GA - Gabon 1
GD - Grenada 1
GT - Guatemala 1
HR - Croazia 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
NG - Nigeria 1
NO - Norvegia 1
NP - Nepal 1
OM - Oman 1
PE - Perù 1
PS - Palestinian Territory 1
SM - San Marino 1
TT - Trinidad e Tobago 1
UG - Uganda 1
Totale 16.125
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Città #
Singapore 1.027
Chandler 767
Jacksonville 731
San Jose 640
Dublin 564
Southend 394
Ashburn 329
Beijing 257
Princeton 244
Dallas 242
Izmir 219
Nanjing 217
Council Bluffs 201
Dearborn 196
Los Angeles 147
New York 140
Cambridge 124
Chieti 121
Santa Clara 105
Tongling 104
Wilmington 101
Ho Chi Minh City 94
Munich 81
Nanchang 76
The Dalles 73
Boardman 71
Ann Arbor 62
Hanoi 61
Altamura 60
Buffalo 57
Moscow 57
Shenyang 56
Rome 48
Columbus 46
Woodbridge 44
Hebei 43
Kunming 38
Hong Kong 37
Tianjin 36
Hefei 34
Seoul 28
Warsaw 28
Helsinki 27
São Paulo 27
Chennai 25
Tokyo 25
Houston 24
Chicago 23
Jiaxing 23
Norwalk 23
Brussels 22
Denver 22
Changsha 21
Jinan 21
Seattle 21
Grevenbroich 20
Johannesburg 20
Orem 20
Ardabil 19
Brooklyn 19
Pescara 19
Redondo Beach 19
Boston 18
Dong Ket 18
Frankfurt am Main 18
Kraków 18
San Francisco 18
Hangzhou 17
Kocaeli 17
Montreal 17
Phoenix 17
Toronto 17
Düsseldorf 16
Milan 16
Washington 16
Atlanta 15
London 15
Auburn Hills 14
Haiphong 14
Ningbo 14
Orange 14
Poplar 14
Turku 13
Dhaka 12
Biên Hòa 11
Mexico City 11
Mumbai 11
Stockholm 11
Ankara 10
Da Nang 10
Guangzhou 10
Leawood 10
Zhengzhou 10
Augusta 9
Bexley 9
Collecorvino 9
Naples 9
New Delhi 9
Belo Horizonte 8
Brno 8
Totale 8.943
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Nome #
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 774
Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudopeptides 752
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 409
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 205
2,5-Diketopiperazines as neuroprotective agents 196
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 175
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 162
Synthesis of a novel TRH-related sulphonamido peptide 161
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 161
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 159
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 159
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 156
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 155
GPE and GPE analogues as promising neuroprotective agents 155
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 152
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 150
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 148
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 148
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 145
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 145
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 143
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 143
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 142
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 140
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 139
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 139
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 138
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 138
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 138
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 136
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 135
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 135
Synthesis and activity of novel TRH analogues targeted to TRH-R2 134
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 134
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 134
Hypotaurine disproportionation reaction: identification of products 133
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 133
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 133
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 133
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 131
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 131
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 130
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 130
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 129
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 129
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 129
Design and synthesis of glutathione analogues 128
Backbone-modified glutathione analogues 128
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 128
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 127
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 127
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 127
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 126
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 126
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 126
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 125
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 125
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 125
Novel cyclic biphalin analogue with improved antinociceptive properties 125
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 125
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 124
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 122
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 122
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 121
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 120
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 120
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 120
N-acylamino derivatives related to the peptide portion of ergopeptines 119
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 119
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 118
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 117
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 116
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 116
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 116
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 115
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 113
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 113
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 112
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 112
cis-4-Amino-l-proline Residue As a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues: Part 2 112
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 111
Sintesi e conformazione di pseudopeptidi 110
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 110
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 110
Synthesis of GPE analogues as potential neuroprotective agents 110
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 108
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 108
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 107
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 106
Multifuctional L-Dopa Codrugs Containing Antioxidant Molecules 106
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 106
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 105
Cyclization under mild conditions of salicyloyl-dipeptides 105
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 105
Prodrug approach for increasing cellular glutathione levels 105
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 103
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 101
New potent caspase-3 inhibitors as anti-apoptotic agents 100
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 100
Psi(SO2-NH) transition state isosteres of peptides. Synthesis of the glutathione disulfide analogue [Glu-psi(SO2-NH)-Cys-Gly]2 97
Totale 14.404
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Categoria #
all - tutte 64.016
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 64.016
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022463 0 0 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/20252.008 109 313 284 49 24 125 42 97 151 91 228 495
2025/20265.344 424 161 355 477 432 292 709 225 1.716 320 182 51
2026/2027359 82 232 45 0 0 0 0 0 0 0 0 0
Totale 16.239