IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
NA - Nord America 4.024
EU - Europa 4.005
AS - Asia 2.669
SA - Sud America 196
AF - Africa 15
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 2
Totale 10.918
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Nazione #
US - Stati Uniti d'America 3.978
CN - Cina 1.030
SG - Singapore 872
UA - Ucraina 696
IT - Italia 616
IE - Irlanda 572
GB - Regno Unito 499
SE - Svezia 490
FR - Francia 453
TR - Turchia 419
DE - Germania 306
IN - India 215
BR - Brasile 177
FI - Finlandia 152
RU - Federazione Russa 92
PL - Polonia 35
CA - Canada 27
VN - Vietnam 27
BE - Belgio 26
HK - Hong Kong 22
IR - Iran 22
NL - Olanda 19
BD - Bangladesh 15
GR - Grecia 12
JP - Giappone 11
LT - Lituania 10
MX - Messico 10
CZ - Repubblica Ceca 9
ES - Italia 8
IL - Israele 8
IQ - Iraq 8
EU - Europa 7
AR - Argentina 6
SA - Arabia Saudita 6
EC - Ecuador 5
MA - Marocco 5
CH - Svizzera 4
CL - Cile 3
ZA - Sudafrica 3
AU - Australia 2
HU - Ungheria 2
JM - Giamaica 2
KE - Kenya 2
KR - Corea 2
NI - Nicaragua 2
PK - Pakistan 2
SY - Repubblica araba siriana 2
TN - Tunisia 2
UY - Uruguay 2
UZ - Uzbekistan 2
AE - Emirati Arabi Uniti 1
AM - Armenia 1
AT - Austria 1
CG - Congo 1
CO - Colombia 1
DO - Repubblica Dominicana 1
EE - Estonia 1
EG - Egitto 1
GD - Grenada 1
HR - Croazia 1
JO - Giordania 1
LB - Libano 1
PA - Panama 1
PE - Perù 1
PH - Filippine 1
PY - Paraguay 1
SM - San Marino 1
SV - El Salvador 1
TH - Thailandia 1
TT - Trinidad e Tobago 1
UG - Uganda 1
Totale 10.918
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Città #
Chandler 767
Jacksonville 731
Singapore 656
Dublin 564
Southend 394
Princeton 244
Izmir 219
Nanjing 217
Beijing 200
Dearborn 196
Cambridge 124
Chieti 117
Ashburn 115
Tongling 104
Wilmington 101
New York 98
Munich 81
Nanchang 76
The Dalles 73
Boardman 71
Santa Clara 69
Ann Arbor 62
Altamura 60
Shenyang 56
Los Angeles 46
Woodbridge 44
Hebei 43
Rome 40
Kunming 38
Tianjin 36
Hefei 34
Helsinki 24
Jiaxing 23
Norwalk 23
Brussels 22
Hong Kong 22
Changsha 21
Jinan 21
Grevenbroich 20
Ardabil 19
Pescara 19
Dong Ket 18
Kraków 18
Seattle 18
Hangzhou 17
Kocaeli 17
Düsseldorf 16
Frankfurt am Main 16
Washington 15
Auburn Hills 14
Ningbo 14
Orange 14
San Francisco 14
Boston 13
Chicago 13
Moscow 12
São Paulo 12
Dallas 11
London 11
Guangzhou 10
Leawood 10
Tokyo 10
Zhengzhou 10
Augusta 9
Bexley 9
Collecorvino 9
Houston 9
Toronto 9
Brno 8
Brooklyn 8
Lanzhou 8
Milan 8
San Mateo 8
Warsaw 8
Changchun 7
Dhaka 7
Florence 7
Naples 7
Romola 7
Roubaix 7
Shanghai 7
Taizhou 7
Wroclaw 7
Belo Horizonte 6
Fuzhou 6
Mumbai 6
Ottawa 6
Rio de Janeiro 6
Teramo 6
Turku 6
Bari 5
Bonn 5
Charlotte 5
Falls Church 5
Haikou 5
New Delhi 5
Perugia 5
Simi Valley 5
Campinas 4
Columbus 4
Totale 6.439
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Nome #
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 335
Synthesis of a novel TRH-related sulphonamido peptide 130
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 130
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 127
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 124
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 122
2,5-Diketopiperazines as neuroprotective agents 120
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 118
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 118
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 118
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 116
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 115
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 113
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 112
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 110
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 110
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 109
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 109
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 109
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 109
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 108
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 106
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 106
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 105
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 105
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 103
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 103
GPE and GPE analogues as promising neuroprotective agents 102
Synthesis and activity of novel TRH analogues targeted to TRH-R2 101
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 101
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 101
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 101
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 100
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 100
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 98
Design and synthesis of glutathione analogues 97
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 97
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 96
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 96
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 96
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 95
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 95
Hypotaurine disproportionation reaction: identification of products 94
Backbone-modified glutathione analogues 94
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 94
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 94
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 93
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 93
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 93
Sintesi e conformazione di pseudopeptidi 92
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 92
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 92
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 90
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 90
N-acylamino derivatives related to the peptide portion of ergopeptines 89
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 89
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 89
Novel cyclic biphalin analogue with improved antinociceptive properties 89
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 88
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 88
Synthesis of GPE analogues as potential neuroprotective agents 88
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 87
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 87
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 87
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 86
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 86
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 86
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 86
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 86
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 85
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 85
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 85
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 85
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 84
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 84
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 83
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 83
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 83
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 83
Prodrug approach for increasing cellular glutathione levels 82
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 82
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 81
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 79
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 79
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 79
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 78
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 78
Peptidic alfa-acylimino derivatives. Synthesis, properties and intramolecular interactions 78
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 78
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 77
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 77
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 77
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 76
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 76
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 76
psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine. 75
Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudopeptides 74
SYNTHESIS OF (S)-5,6-DIBROMO-TRYPTOPHAN DERIVATIVES AS BUILDING BLOCKS FOR PEPTIDE CHEMISTRY 74
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 74
Synthesys and evaluation of new endomorphin analogues modified at the Pro2 residue 72
Totale 9.650
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Categoria #
all - tutte 45.995
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 45.995
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021676 0 1 125 6 88 149 9 5 39 132 77 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/20252.008 109 313 284 49 24 125 42 97 151 91 228 495
2025/2026496 424 72 0 0 0 0 0 0 0 0 0 0
Totale 11.032