IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
EU - Europa 3.625
NA - Nord America 3.450
AS - Asia 1.457
Continente sconosciuto - Info sul continente non disponibili 7
SA - Sud America 3
OC - Oceania 2
AF - Africa 1
Totale 8.545
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Nazione #
US - Stati Uniti d'America 3.440
CN - Cina 752
UA - Ucraina 694
IE - Irlanda 571
IT - Italia 507
SE - Svezia 487
GB - Regno Unito 466
TR - Turchia 414
FR - Francia 408
DE - Germania 208
IN - India 198
FI - Finlandia 131
RU - Federazione Russa 91
SG - Singapore 44
IR - Iran 22
PL - Polonia 21
VN - Vietnam 18
GR - Grecia 12
BE - Belgio 11
CA - Canada 8
CZ - Repubblica Ceca 8
EU - Europa 7
IL - Israele 5
AU - Australia 2
CL - Cile 2
ES - Italia 2
HU - Ungheria 2
KR - Corea 2
NL - Olanda 2
AR - Argentina 1
AT - Austria 1
CH - Svizzera 1
EG - Egitto 1
HR - Croazia 1
JP - Giappone 1
MX - Messico 1
PA - Panama 1
SM - San Marino 1
TH - Thailandia 1
Totale 8.545
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Città #
Chandler 767
Jacksonville 730
Dublin 563
Southend 394
Princeton 244
Izmir 218
Nanjing 217
Dearborn 196
Cambridge 123
Chieti 117
Beijing 107
Wilmington 101
Ashburn 98
New York 86
Nanchang 76
Boardman 71
Ann Arbor 62
Altamura 60
Shenyang 56
Woodbridge 44
Hebei 43
Kunming 38
Tianjin 36
Los Angeles 31
Singapore 29
Jiaxing 23
Norwalk 23
Changsha 21
Jinan 21
Grevenbroich 20
Ardabil 19
Rome 19
Dong Ket 18
Kraków 18
Pescara 18
Hangzhou 17
Kocaeli 17
Düsseldorf 16
Seattle 15
Washington 15
Auburn Hills 14
Ningbo 14
Orange 14
Moscow 12
Guangzhou 10
Helsinki 10
Leawood 10
Zhengzhou 10
Augusta 9
Brussels 9
Collecorvino 9
Houston 9
Brno 8
Lanzhou 8
San Mateo 8
Florence 7
Hefei 7
Taizhou 7
Changchun 6
Chicago 6
Milan 6
Mumbai 6
Naples 6
Teramo 6
Bari 5
Bonn 5
Falls Church 5
Fuzhou 5
Haikou 5
Shanghai 5
Simi Valley 5
Elice 4
Silvi 4
Andover 3
Brescia 3
Fairport 3
Monmouth Junction 3
Munich 3
Palermo 3
Perugia 3
Rovereto 3
Toronto 3
Trieste 3
Bangalore 2
Bonate Sotto 2
Bussolengo 2
Cedar Knolls 2
Cepagatti 2
Chengdu 2
Clifton 2
Dallas 2
Fairfield 2
Farindola 2
Fiume Veneto 2
Genoa 2
Gwangsan-gu 2
Harbin 2
Ithaca 2
Jesolo 2
Legnano 2
Totale 5.105
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Nome #
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 213
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 101
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 100
Synthesis of a novel TRH-related sulphonamido peptide 100
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 96
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 95
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 95
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 92
2,5-Diketopiperazines as neuroprotective agents 90
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 90
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 90
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 89
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 87
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 87
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 86
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 85
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 83
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 83
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 83
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 83
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 82
GPE and GPE analogues as promising neuroprotective agents 82
Synthesis and activity of novel TRH analogues targeted to TRH-R2 81
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 81
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 81
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 81
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 80
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 80
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 80
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 78
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 78
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 77
Sintesi e conformazione di pseudopeptidi 77
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 77
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 77
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 77
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 77
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 76
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 76
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 75
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 75
Design and synthesis of glutathione analogues 74
Hypotaurine disproportionation reaction: identification of products 74
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 74
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 74
Novel cyclic biphalin analogue with improved antinociceptive properties 74
N-acylamino derivatives related to the peptide portion of ergopeptines 73
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 73
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 73
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 73
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 73
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 72
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 72
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 72
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 72
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 72
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 72
Synthesis of GPE analogues as potential neuroprotective agents 72
Backbone-modified glutathione analogues 71
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 71
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 70
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 70
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 70
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 70
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 70
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 70
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 69
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 69
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 68
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 68
Prodrug approach for increasing cellular glutathione levels 68
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 68
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 67
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 67
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 67
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 66
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 66
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 66
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 66
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 66
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 66
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 65
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 65
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 64
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 64
Peptidic alfa-acylimino derivatives. Synthesis, properties and intramolecular interactions 64
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 63
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 63
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 63
psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine. 62
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 62
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 62
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 61
Synthesys and evaluation of new endomorphin analogues modified at the Pro2 residue 61
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 61
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 61
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 61
SYNTHESIS OF (S)-5,6-DIBROMO-TRYPTOPHAN DERIVATIVES AS BUILDING BLOCKS FOR PEPTIDE CHEMISTRY 61
Synthesis and biological evaluation of oligopeptides with antioxidant activity useful for treatment of neurodegenerative diseases 60
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 60
Totale 7.567
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Categoria #
all - tutte 30.308
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 30.308
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.203 0 123 5 71 117 162 258 165 23 123 150 6
2020/2021804 128 1 125 6 88 149 9 5 39 132 77 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/2025131 109 22 0 0 0 0 0 0 0 0 0 0
Totale 8.659