IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
EU - Europa 3.976
NA - Nord America 3.926
AS - Asia 2.426
SA - Sud America 172
AF - Africa 12
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 2
Totale 10.521
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Nazione #
US - Stati Uniti d'America 3.886
CN - Cina 869
SG - Singapore 821
UA - Ucraina 695
IT - Italia 613
IE - Irlanda 572
GB - Regno Unito 494
SE - Svezia 489
FR - Francia 453
TR - Turchia 418
DE - Germania 297
IN - India 208
BR - Brasile 155
FI - Finlandia 152
RU - Federazione Russa 91
PL - Polonia 32
BE - Belgio 26
CA - Canada 23
IR - Iran 22
HK - Hong Kong 20
VN - Vietnam 19
NL - Olanda 18
GR - Grecia 12
BD - Bangladesh 11
CZ - Repubblica Ceca 9
LT - Lituania 9
JP - Giappone 8
MX - Messico 8
EU - Europa 7
IL - Israele 7
AR - Argentina 6
IQ - Iraq 6
SA - Arabia Saudita 5
CH - Svizzera 4
ES - Italia 4
MA - Marocco 4
CL - Cile 3
EC - Ecuador 3
AU - Australia 2
HU - Ungheria 2
JM - Giamaica 2
KR - Corea 2
NI - Nicaragua 2
SY - Repubblica araba siriana 2
TN - Tunisia 2
UY - Uruguay 2
UZ - Uzbekistan 2
ZA - Sudafrica 2
AE - Emirati Arabi Uniti 1
AM - Armenia 1
AT - Austria 1
CG - Congo 1
CO - Colombia 1
DO - Repubblica Dominicana 1
EE - Estonia 1
EG - Egitto 1
GD - Grenada 1
HR - Croazia 1
KE - Kenya 1
LB - Libano 1
PA - Panama 1
PE - Perù 1
PH - Filippine 1
PK - Pakistan 1
PY - Paraguay 1
SM - San Marino 1
SV - El Salvador 1
TH - Thailandia 1
TT - Trinidad e Tobago 1
UG - Uganda 1
Totale 10.521
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Città #
Chandler 767
Jacksonville 730
Singapore 649
Dublin 564
Southend 394
Princeton 244
Izmir 219
Nanjing 217
Dearborn 196
Cambridge 124
Chieti 117
Beijing 107
Ashburn 105
Tongling 104
Wilmington 101
New York 92
Nanchang 76
Munich 73
The Dalles 73
Boardman 71
Santa Clara 68
Ann Arbor 62
Altamura 60
Shenyang 56
Woodbridge 44
Hebei 43
Los Angeles 39
Kunming 38
Rome 38
Tianjin 36
Helsinki 24
Jiaxing 23
Norwalk 23
Brussels 22
Changsha 21
Jinan 21
Grevenbroich 20
Hong Kong 20
Ardabil 19
Pescara 19
Dong Ket 18
Kraków 18
Hangzhou 17
Kocaeli 17
Seattle 17
Düsseldorf 16
Frankfurt am Main 16
Washington 15
Auburn Hills 14
Ningbo 14
Orange 14
Moscow 12
San Francisco 11
Chicago 10
Guangzhou 10
Leawood 10
Zhengzhou 10
Augusta 9
Bexley 9
Collecorvino 9
Houston 9
London 9
Toronto 9
Brno 8
Lanzhou 8
Milan 8
San Mateo 8
São Paulo 8
Boston 7
Changchun 7
Dallas 7
Florence 7
Hefei 7
Naples 7
Romola 7
Roubaix 7
Shanghai 7
Taizhou 7
Tokyo 7
Wroclaw 7
Fuzhou 6
Mumbai 6
Ottawa 6
Teramo 6
Turku 6
Bari 5
Belo Horizonte 5
Bonn 5
Falls Church 5
Haikou 5
Perugia 5
Rio de Janeiro 5
Simi Valley 5
Warsaw 5
Brooklyn 4
Campinas 4
Columbus 4
Curitiba 4
Dhaka 4
Elice 4
Totale 6.235
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Nome #
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 326
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 128
Synthesis of a novel TRH-related sulphonamido peptide 124
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 123
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 120
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 119
2,5-Diketopiperazines as neuroprotective agents 116
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 116
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 115
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 114
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 112
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 112
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 111
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 108
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 107
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 106
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 106
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 105
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 105
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 105
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 104
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 103
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 103
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 101
Synthesis and activity of novel TRH analogues targeted to TRH-R2 100
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 100
GPE and GPE analogues as promising neuroprotective agents 100
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 98
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 98
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 98
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 97
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 96
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 96
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 95
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 94
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 94
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 93
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 92
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 92
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 91
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 91
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 91
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 91
Design and synthesis of glutathione analogues 90
Backbone-modified glutathione analogues 90
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 90
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 89
Sintesi e conformazione di pseudopeptidi 89
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 89
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 89
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 89
Hypotaurine disproportionation reaction: identification of products 88
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 88
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 87
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 87
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 86
Novel cyclic biphalin analogue with improved antinociceptive properties 86
N-acylamino derivatives related to the peptide portion of ergopeptines 85
Synthesis of GPE analogues as potential neuroprotective agents 85
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 85
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 84
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 84
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 83
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 83
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 83
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 83
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 82
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 82
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 82
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 82
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 82
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 81
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 81
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 81
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 81
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 81
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 81
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 80
Prodrug approach for increasing cellular glutathione levels 80
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 80
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 79
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 79
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 77
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 77
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 77
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 77
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 75
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 75
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 75
Peptidic alfa-acylimino derivatives. Synthesis, properties and intramolecular interactions 75
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 74
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 74
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 74
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 73
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 73
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 72
psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine. 71
SYNTHESIS OF (S)-5,6-DIBROMO-TRYPTOPHAN DERIVATIVES AS BUILDING BLOCKS FOR PEPTIDE CHEMISTRY 71
Synthesis and biological evaluation of oligopeptides with antioxidant activity useful for treatment of neurodegenerative diseases 70
Identification of an oxidation product of aminoethylcysteine ketimine dimer 70
Totale 9.312
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Categoria #
all - tutte 44.574
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.574
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021804 128 1 125 6 88 149 9 5 39 132 77 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/20252.008 109 313 284 49 24 125 42 97 151 91 228 495
2025/202699 99 0 0 0 0 0 0 0 0 0 0 0
Totale 10.635