IRIS
PINNEN, Francesco Enrico
 Distribuzione geografica
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Continente #
EU - Europa 3.842
NA - Nord America 3.789
AS - Asia 2.013
SA - Sud America 87
Continente sconosciuto - Info sul continente non disponibili 7
AF - Africa 6
OC - Oceania 2
Totale 9.746
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Nazione #
US - Stati Uniti d'America 3.763
CN - Cina 765
UA - Ucraina 695
IT - Italia 607
IE - Irlanda 572
SG - Singapore 555
SE - Svezia 487
GB - Regno Unito 476
FR - Francia 418
TR - Turchia 416
DE - Germania 244
IN - India 198
FI - Finlandia 148
RU - Federazione Russa 91
BR - Brasile 74
BE - Belgio 26
IR - Iran 22
PL - Polonia 21
HK - Hong Kong 19
VN - Vietnam 18
NL - Olanda 17
CA - Canada 16
GR - Grecia 12
CZ - Repubblica Ceca 9
EU - Europa 7
LT - Lituania 7
IL - Israele 5
AR - Argentina 4
BD - Bangladesh 4
CH - Svizzera 4
IQ - Iraq 4
CL - Cile 3
MA - Marocco 3
MX - Messico 3
AU - Australia 2
EC - Ecuador 2
ES - Italia 2
HU - Ungheria 2
JM - Giamaica 2
KR - Corea 2
NI - Nicaragua 2
AM - Armenia 1
AT - Austria 1
CG - Congo 1
CO - Colombia 1
DO - Repubblica Dominicana 1
EE - Estonia 1
EG - Egitto 1
HR - Croazia 1
JP - Giappone 1
PA - Panama 1
PE - Perù 1
PH - Filippine 1
PY - Paraguay 1
SM - San Marino 1
SV - El Salvador 1
TH - Thailandia 1
TN - Tunisia 1
UY - Uruguay 1
UZ - Uzbekistan 1
Totale 9.746
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Città #
Chandler 767
Jacksonville 730
Dublin 564
Southend 394
Singapore 386
Princeton 244
Izmir 219
Nanjing 217
Dearborn 196
Cambridge 124
Chieti 117
Beijing 107
Ashburn 102
Wilmington 101
New York 86
Nanchang 76
Boardman 71
The Dalles 71
Santa Clara 67
Ann Arbor 62
Altamura 60
Shenyang 56
Woodbridge 44
Hebei 43
Kunming 38
Rome 38
Tianjin 36
Munich 33
Los Angeles 31
Helsinki 24
Jiaxing 23
Norwalk 23
Brussels 22
Changsha 21
Jinan 21
Grevenbroich 20
Ardabil 19
Hong Kong 19
Pescara 19
Dong Ket 18
Kraków 18
Hangzhou 17
Kocaeli 17
Düsseldorf 16
Seattle 15
Washington 15
Auburn Hills 14
Ningbo 14
Orange 14
Moscow 12
Guangzhou 10
Leawood 10
Zhengzhou 10
Augusta 9
Collecorvino 9
Houston 9
Brno 8
Lanzhou 8
Milan 8
San Mateo 8
Changchun 7
Florence 7
Hefei 7
Romola 7
Shanghai 7
Taizhou 7
Toronto 7
Chicago 6
Fuzhou 6
Mumbai 6
Naples 6
Ottawa 6
Teramo 6
Bari 5
Bonn 5
Falls Church 5
Haikou 5
London 5
Perugia 5
Simi Valley 5
Elice 4
Genoa 4
Messina 4
Silvi 4
Treviso 4
Andover 3
Belo Horizonte 3
Brescia 3
Campinas 3
Fairport 3
Frankfurt am Main 3
Legnano 3
Marília 3
Monmouth Junction 3
Palermo 3
Rovato 3
Rovereto 3
Trieste 3
Bangalore 2
Bologna 2
Totale 5.733
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Nome #
Il cofarmaco ibuprofene-glutatione quale nuovo potenziale agente anti-alzheimer 315
A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation. 120
Synthesis of a novel TRH-related sulphonamido peptide 118
(R)-α-Lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities 116
Sintesi di trans-2-ammino-5(o 6)-cloro-6(o 5)-idrossi-1-fenil-2,3-diidro-1H-indani quali precursori di derivati a potenziale affinità per i recettori della dopamina 114
Pseudopeptidi bioattivi. Modificazioni della porzione gamma-glutamilica del glutatione: isosteri psi (SO2NH) dello stato di transizione e gamma-aza analoghi 113
Synthesis and preliminary pharmacological evaluation of 2,3,4,8,13a-hexahydro-1H-benzo(5,6)cyclohepta(1,2,3-ef)(3)benzazepine-6,7-diol derivatives as dopamine receptor ligands 110
2,5-Diketopiperazines as neuroprotective agents 108
Synthesis and evaluation of trans-2-amino-5(or 6)-chloro-6(or 5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 107
Cofarmaci L-Dopa-antiossidanti solforati quali nuovi potenziali agenti anti-Parkinson 104
(R)-alpha-Lipoic Acid–Gly-L-Pro-L-Glu(OMe)-OMe Codrug as Multifunctional Agent for Neurodegenerative Diseases, with Antioxidant and Neuroprotective Properties 103
sintesi ed attività di due analoghi del glutatione a conformazione ristretta 101
Synthesis of Short Cationic Antimicrobial Peptidomimetics Containing Arginine Analogs 101
A novel TRH analog containing a gamma-sultam residue replacing the pyroglutamic acid 99
Synthesis and neuromodulatory effects of TRH-related peptides: inhibitory activity on catecholamine release in vitro 99
Synthesis and activity of fluorescent glutathione S-conjugates as novel GST inhibitors 98
Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease 98
New pharmacologic tools against Parkinson's disease: L-Dopa-antioxidant codrugs containing the methionine residue 98
Sintesi di trans-2-ammino-1-fenil-5-fluoro-6-idrossi (e 6-fluoro-5-idrossi)-2,3-diidro-1H-indeni quali potenziali ligandi per i recettori dopaminergici 97
CNS delivery of L-Dopa by a new Hybrid Glutathione-Methionine peptidomimetic prodrug 97
A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells 97
GPE and GPE analogues as promising neuroprotective agents 95
Ytterbium triflate catalysed Meerwein–Ponndorf–Verley (MPV) reduction 95
N-(tert-butilossicarbonil)-beta,beta-ciclopentil-cisteina (acetamidometil)-metil estere per la sintesi di nuovi derivati peptidomimetici 94
Synthesis of a novel glutathione analogue as potential inhibitor of glutathione-S-transferase 93
N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity 93
Synthesis and Study of L-Dopa-Glutathione Codrugs as New Anti-Parkinson Agents with Free Radical Scavenging Properties. 92
Synthesis and activity of novel TRH analogues targeted to TRH-R2 91
Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an alfa-aza-phenylalanine-containing oxa-cyclol 91
synthesis and Activity of L-Dopa-Thiol antioxidant Co-drugs and New anti-PArkinson Agents with free Radical Scavenging Properties 91
N-(tert)-Butyloxycarbonyl-beta,beta-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives 89
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues 89
Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1- phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands 88
Evaluation of 2,3,4,8,13a hexahydro-1H-Benzo[5,6]cyclohepta-6,7-dihydroxy[1,2,3-ef][3]benzazepine derivatives as dopamine receptor ligands 87
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine (S-(2-aminoethyl)-L-cysteine) 86
Synthesis of (S)-5,6-dibromo-tryptophan derivatives as building blocks for peptide chemistry 86
Peptidi ibridi endomorfina-2/DAMGO: progettazione, sinteti e valutazione biologica 86
Design and synthesis of glutathione analogues 85
Synthesis and biological evaluation of a novel pyroglutamil-modified TRH analogue 85
Detection of levodopa, dopamine and its metabolites in rat striatum dialysates following peripheral administration of L-DOPA prodrugs by mean of HPLC-EC 85
Evaluation of rat striatal L-Dopa and DA concentration after intraperitoneal administration of L- Dopa prodrugs in liposomal formulations 85
synthesis and biological evaluation as anti-Parkinson agent of an analogue of Glutathione-L-Dopa containing methionine in place of the cysteinil residue 85
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione 85
Sintesi e conformazione di pseudopeptidi 83
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease 83
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation 83
Hypotaurine disproportionation reaction: identification of products 82
Nine-membered cyclodepsitripeptide systems containing the retroisomeric sequence of ergot-peptides 82
Sintesi di nuove di- e tripeptidil-aldeidi quali potenziali inibitori reversibili della caspasi-3 umana 82
Nuovi S-coniugati del glutatione ad attività inibitoria nei confronti delle GST umane 82
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation 82
Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer 82
(Acyloxy)Alkoxy Moiety as Amino Acids Protecting Group for the Synthesis of (R,R)-2,7 Diaminosuberic Acid via RCM 82
Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists 82
Novel cyclic biphalin analogue with improved antinociceptive properties 81
Backbone-modified glutathione analogues 79
N-acylamino derivatives related to the peptide portion of ergopeptines 79
Synthesis and evaluation of new endomorphoin analogues modified at the Pro2 residue 79
Biological active analogues of the opioid peptide Biphalin: mixed a/b3-peptides 79
The Evolution of Peptide Synthesis: From Early Days to Small Molecular Machines 79
Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker 79
Pharmacological profile of new fluorinated analogue of Biphalin with non-hydrazide linker (AM94): an update 78
Synthesis and properties of (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid, a new gamma-sultam analogue of pyroglutamic acid 77
Endomorphin-1 stimulates norepinephrine release in rat hypothalamus. 77
Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control 77
Synthesis and biological activity of new inhibitors of pantetheine hydrolase 76
Proline-Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues 76
Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage 76
Diazabicycloundecene (DBU)-mediated lactonization of carboxy-activated N-acyl-seryl-prolyl-prolines 76
Synthesis of GPE analogues as potential neuroprotective agents 76
Approaches to pseudopeptidic ergopeptines. Part 2. Consequences of the incorporation of an alfa-azaproline residue into the oxacyclolic system 75
Synthesis and activity of the glutathione analogue gamma-(L-gamma-oxaglutamyl)-L-cysteinyl-glycine 75
Molecular mechanism undelying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model 75
A new chromogenic substrate for pantetheine hydrolase and vanin proteins 75
L-Dopa- and dopamine- (R)-α-lipoic acid conjugates as multifunctional codrugs with antioxidant properties 74
Facile transformation of glutamic acid into proline residue inside a tripeptide backbone 74
Prodrug approach for increasing cellular glutathione levels 74
Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues 74
New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4′ positions and non-hydrazine linkers 74
Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate 74
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2 73
The cis-4-amino-l-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues 72
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine. 70
Progettazione, sintesi e valutazione dell' attività di analoghi ciclici e lineari dell' endomorfina 2 contenenti un residuo di 4-(2)NH2-Pro-OH (cAmp) in posizione 2 70
Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-kB and Nrf2 signalling 70
Peptidic alfa-acylimino derivatives. Synthesis, properties and intramolecular interactions 70
Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. 70
Bicyclic peptides: Solution conformation and Ca++ binding of the heterodetic bicyclic decapeptide cyclo(Glu-Leu-Pro-Gly-Ser-Ile-Pro-Ala)-cyclo(Phe-Gly)’ 69
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as Cysteine Conformationally Restricted Analogue. Synthetic Protocol for Adt Containing Peptides 69
Structure-Activity relationships of biphalin analogs and their biological evaluation on opioid receptors 69
Ten-membered cyclotripeptides III. Synthesis and conformation of cyclo(-MebetaAla-Phe-Pro-) and cyclo(-MebetaAla-Phe-DPro-) 68
Synthesis and biological evaluation of oligopeptides with antioxidant activity useful for treatment of neurodegenerative diseases 68
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold: Synthesis and bioactivity 68
Long acting opioid peptides: in vitro and in vivo biological evaluation of new fluorinated analogues of Biphalin 68
Approaches to pseudopeptidic ergopeptines. Part 3. Consequences of the incorporation of an α-azaphenylalanine residue into the ergotamine oxa-cyclolic system 68
synthesis and Activity of Endomorphin-1 and 2 analogues Incorporating Azetidine-(S)-2-carboxylic acid and Azetidine-3-carboxylic acid in place of native proline 67
Design, synthesis and evaluation of new endomorphin analogues incorporating constrained aminoacids in place of Pro2 residue 67
Identification of an oxidation product of aminoethylcysteine ketimine dimer 67
psi(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine. 66
SYNTHESIS OF (S)-5,6-DIBROMO-TRYPTOPHAN DERIVATIVES AS BUILDING BLOCKS FOR PEPTIDE CHEMISTRY 66
Totale 8.637
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Categoria #
all - tutte 41.547
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 41.547
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020156 0 0 0 0 0 0 0 0 0 0 150 6
2020/2021804 128 1 125 6 88 149 9 5 39 132 77 45
2021/2022498 18 17 2 65 91 8 14 34 45 8 59 137
2022/20232.044 135 242 121 237 217 421 113 173 267 39 46 33
2023/2024888 83 36 52 23 46 300 227 30 7 18 12 54
2024/20251.332 109 313 284 49 24 125 42 97 151 91 47 0
Totale 9.860